Hexum T D, Russett L R
Brain Res. 1987 Mar 17;406(1-2):370-2. doi: 10.1016/0006-8993(87)90809-2.
Nicotine administration, using mini-osmotic pumps, to male guinea pigs (31 micrograms/h for 10 days) resulted in a significant elevation of plasma epinephrine and enkephalin-like peptides but not norepinephrine. The increase in plasma epinephrine and enkephalin-like peptides was not accompanied by corresponding alterations in either adrenal medullary synthesis or blood pressure and heart rate. These findings may provide a partial explanation for the observation that chronic smoking does not induce hypertension.
使用微型渗透泵对雄性豚鼠进行尼古丁给药（31微克/小时，持续10天）导致血浆肾上腺素和脑啡肽样肽显著升高，但去甲肾上腺素未升高。血浆肾上腺素和脑啡肽样肽的增加并未伴随着肾上腺髓质合成或血压及心率的相应改变。这些发现可能为长期吸烟不会诱发高血压这一观察结果提供部分解释。
