Kim Byung Jin, Kang Jeong Gyu, Kim Ji Hye, Seo Dae Chul, Sung Ki Chul, Kim Bum Soo, Kang Jin Ho
Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 03181, Korea.
J Clin Med. 2019 Aug 16;8(8):1238. doi: 10.3390/jcm8081238.
No study has reported the relationship between secondhand smoke (SHS) exposure and hypertension in self-reported never-smokers verified by nicotine metabolite. The aim of this study is to determine the relationship between SHS exposure and hypertension in self-reported and cotinine-verified never-smokers. A total of 106,268 self-reported never-smokers, verified as nonsmokers by urinary cotinine, who participated in Kangbuk Samsung Cohort study (KSCS) between 2012 and 2016 were included. Cotinine-verified nonsmokers were defined as individuals having urinary cotinine <50 ng/mL. SHS exposure was defined as current exposure to passive smoke indoors at home or the workplace. The multivariate regression model revealed that SHS exposure was associated with hypertension (odds ratio (OR) (95% confidence interval (CI)), 1.16 (1.08, 1.24)). Current SHS exposure that has been exposed to home SHS (1.22 (1.11, 1.33)) as well as current SHS exposure only at the workplace (1.15 (1.02, 1.29)) significantly increased the ORs for hypertension compared to no SHS exposure. There was no significant gender interaction for the relationships between SHS exposure and hypertension. This study showed that SHS exposure was significantly associated with hypertension in self-reported never-smokers verified as nonsmokers by urinary cotinine, suggesting necessity of health program and stricter smoking regulation to reduce the risk of hypertension.
尚无研究报道经尼古丁代谢物验证的自我报告从不吸烟者中二手烟暴露与高血压之间的关系。本研究的目的是确定自我报告且经可替宁验证的从不吸烟者中二手烟暴露与高血压之间的关系。纳入了2012年至2016年期间参与江北三星队列研究（KSCS）的106268名自我报告的从不吸烟者，这些人经尿可替宁验证为非吸烟者。经可替宁验证的非吸烟者定义为尿可替宁<50 ng/mL的个体。二手烟暴露定义为当前在家中或工作场所室内接触被动吸烟。多变量回归模型显示，二手烟暴露与高血压相关（比值比（OR）（95%置信区间（CI）），1.16（1.08，1.24））。与无二手烟暴露相比，当前暴露于家庭二手烟（1.22（1.11，1.33））以及仅在工作场所的当前二手烟暴露（1.15（1.02，1.29））显著增加了高血压的OR值。二手烟暴露与高血压之间的关系不存在显著的性别交互作用。本研究表明，在经尿可替宁验证为非吸烟者的自我报告从不吸烟者中，二手烟暴露与高血压显著相关，提示有必要制定健康计划并加强吸烟管制以降低高血压风险。
