Department of Pediatrics, Women and Infants Hospital of Rhode Island, Kilguss Research Institute, The Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI, 02905, USA.
Brown University, Providence, RI, USA.
Reprod Sci. 2022 Dec;29(12):3459-3464. doi: 10.1007/s43032-022-00992-1. Epub 2022 Jun 8.
The majority of research papers published on obstetrical outcomes in Ehlers-Danlos syndrome (EDS) have focused on the contribution of maternal EDS to the risk of poor pregnancy outcomes. The purpose of our study was to further clarify the fetal versus maternal contribution of EDS to poor pregnancy outcomes. A web-based, anonymous questionnaire was developed to collect pregnancy histories of families with a member with EDS. The survey was disseminated via social media through the Ehlers Danlos National Foundation. Population descriptors (age, gender, EDS diagnosis, age of diagnosis) and pregnancy descriptors (number of pregnancies, live births, and birth complications) were collected. To identify fetal and maternal contribution of EDS to poor pregnancy outcomes, three groups were compared based on maternal or infant diagnosis (EDS versus non-EDS). The rate of birth complications, treatment for preterm birth, and occurrence of preterm birth, as well as gestational age at preterm birth, were different depending on maternal/ infant EDS status, and these differences were significant when comparing infant EDS status but not when comparing maternal EDS status. The occurrence of PPROM is increased in the non-EDS mother/EDS infant group compared to both EDS mother/non-EDS infant and EDS mother/EDS infant groups (38.9%, 12.5%, 14.8%, p = 0.025). This study identifies that poor outcomes in EDS pregnancies differ depending on the maternal and the fetal EDS status. These insights into maternal and fetal association with certain poor pregnancy outcomes in pregnancies complicated by EDS can further guide physicians in educating, managing, and treating these women during pregnancy.
大多数关于埃勒斯-当洛斯综合征（EDS）产科结局的研究论文都集中在母亲 EDS 对不良妊娠结局风险的影响上。我们的研究目的是进一步阐明 EDS 对不良妊娠结局的胎儿和母体的影响。我们开发了一个基于网络的匿名问卷，以收集有 EDS 患者的家庭的妊娠史。该调查通过埃勒斯-当洛斯国家基金会通过社交媒体进行传播。收集了人口描述符（年龄、性别、EDS 诊断、诊断年龄）和妊娠描述符（妊娠次数、活产和分娩并发症）。为了确定 EDS 对不良妊娠结局的胎儿和母体贡献，我们根据母亲或婴儿的诊断（EDS 与非 EDS）将三组进行了比较。出生并发症的发生率、早产治疗和早产的发生，以及早产时的胎龄，取决于母亲/婴儿的 EDS 状态，当比较婴儿的 EDS 状态时，这些差异是显著的，但当比较母亲的 EDS 状态时则没有。与 EDS 母亲/非 EDS 婴儿组和 EDS 母亲/EDS 婴儿组相比，非 EDS 母亲/EDS 婴儿组的胎膜早破（PPROM）发生率增加（38.9%、12.5%、14.8%，p=0.025）。这项研究表明，EDS 妊娠的不良结局因母亲和胎儿的 EDS 状态而异。这些关于 EDS 妊娠中母体和胎儿与某些不良妊娠结局之间关联的见解，可以进一步指导医生在妊娠期间对这些女性进行教育、管理和治疗。
