Pranzatelli M R, Gantner C, Snodgrass S R
Brain Res Bull. 1987 Feb;18(2):159-63. doi: 10.1016/0361-9230(87)90185-7.
We studied the effect of 3-acetylpyridine (3-AP) lesions on the serotonergic-myoclonic syndromes evoked by quipazine (QP), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), fenfluramine (FF), and p-chloroamphetamine (PCA) in the adult rat. Eleven behaviors were scored from videotapes by an observer blind to drug status. In unlesioned rats, drugs could be differentiated by forelimb and axial myoclonus, pivoting and backing. All drugs significantly suppressed rearing. 3-AP produced a lasting action-enhanced body tremor which differed from axial myoclonus in its vertical direction and rhythmicity. 3-AP lesions modified the effect of drugs on several behaviors, increasing axial (QP, FF, PCA) and forelimb (5-MeO-DMT, FF, PCA) myoclonus and decreasing locomotor score. Prior lesions with 5,7-dihydroxytryptamine did not prevent the effect of 3-AP or any behaviors of the serotonin syndrome, but had a slight effect on the magnitude of forelimb myoclonus, head weaving, and hunching induced by some drugs. Neither lesion abolished or reduced myoclonus. These data suggest that intact 5-HT terminals are not requisite for the tremorogenic and cytotoxic effect of 3-AP. To the extent that chemical lesions with 3-AP are selective for the inferior olive (IO), the role of the IO in myoclonus in several 5-HT rodent myoclonic models appears to be regulatory rather than stimulatory.
我们研究了3-乙酰吡啶（3-AP）损伤对成年大鼠中由喹哌嗪（QP）、5-甲氧基-N,N-二甲基色胺（5-MeO-DMT）、芬氟拉明（FF）和对氯苯丙胺（PCA）诱发的血清素能性肌阵挛综合征的影响。一名对药物状态不知情的观察者通过录像带对11种行为进行评分。在未损伤的大鼠中，药物可通过前肢和轴向肌阵挛、旋转和后退来区分。所有药物均显著抑制竖毛。3-AP产生了一种持续的、动作增强的身体震颤，其在垂直方向和节律上与轴向肌阵挛不同。3-AP损伤改变了药物对几种行为的影响，增加了轴向（QP、FF、PCA）和前肢（5-MeO-DMT、FF、PCA）肌阵挛，并降低了运动评分。预先用5,7-二羟基色胺损伤并不能阻止3-AP的作用或血清素综合征的任何行为，但对某些药物诱发的前肢肌阵挛、头部摆动和弓背的程度有轻微影响。两种损伤均未消除或减轻肌阵挛。这些数据表明，完整的5-羟色胺能终末对于3-AP的致震颤和细胞毒性作用并非必需。就3-AP化学损伤对下橄榄核（IO）具有选择性而言，IO在几种5-羟色胺能啮齿动物肌阵挛模型中的肌阵挛作用似乎是调节性的而非刺激性的。
