Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China.
Biomed Pharmacother. 2022 Jul;151:113068. doi: 10.1016/j.biopha.2022.113068. Epub 2022 May 27.
The physical and chemical pressures in the tumor microenvironment (TME) play an important role in tumor development by regulating stromal elements, including immune cells. Hypoxia can induce a cascade of events in tumor initiation and development via immune regulation. As a dangerous factor, hypoxia activates multiple signaling pathways to reshape the immune microenvironment, leading to immunosuppression. Consequently, targeting hypoxia in the TME is a potential strategy to prevent immune escape and inhibit malignant tumor progression. In this review, we summarized the role of hypoxia-induced factors in the tumor immune escape process and provide a novel pathway to restrain tumor progression and development.
肿瘤微环境（TME）中的物理和化学压力通过调节基质细胞，包括免疫细胞，在肿瘤发展中起重要作用。缺氧可通过免疫调节在肿瘤起始和发展中诱导级联反应。作为一种危险因子，缺氧通过激活多种信号通路重塑免疫微环境，导致免疫抑制。因此，靶向 TME 中的缺氧是防止免疫逃逸和抑制恶性肿瘤进展的潜在策略。在这篇综述中，我们总结了缺氧诱导因子在肿瘤免疫逃逸过程中的作用，并提供了一种抑制肿瘤进展和发展的新途径。
