R Chandini, R Saranya, Mohideen Khadijah, Nandagopal Preethi, Jayamani Logeswari, Jeyakumaran Sreedevi
Oral and Maxillofacial Pathology, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai, IND.
Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai, IND.
Cureus. 2022 May 5;14(5):e24749. doi: 10.7759/cureus.24749. eCollection 2022 May.
Candida albicans is the most prevalent candidal species in humans. It is the causative agent and is most commonly associated with more than 90% of serious systemic fungal infections. Even though there are numerous anti-fungal agents, new strains of pathogens develop resistance against these agents. In order to prevent resistance, plant-based drugs can be considered as an alternative therapy. Recent studies show that few herbs consist of active ingredients acting against specific pathogens. The aim of the present study is to understand the anti-candidal effect of (Tulsi) based on in-vitro microbial studies. This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement Criteria (PRISMA). Articles were collected from the electronic databases of PubMed and Cochrane till 2021. Anti-microbial studies on and its action against candidal species were included. We excluded clinical trials, reviews, abstract articles, and interventional studies. The selected antimicrobial studies used various phytochemical constituents of Tulsi extract, and the anticandidal properties were measured through the zone of inhibition (ZOI). All studies demonstrated the effective anticandidal property of , suggesting its possible use as an effective and affordable "adjunct" along with standard care for systemic and topical candidal infections. The main components of responsible for anticandidal activity were likely to be eugenol and linalool. However, the mechanism of action of these constituents is unclear. Further research assessing the toxicity, durability, and other assessments followed by clinical trials is necessary to explore the potential of Tulsi in combating oral conditions.
白色念珠菌是人类中最常见的念珠菌种类。它是病原体，最常与超过90%的严重系统性真菌感染相关。尽管有众多抗真菌药物，但新的病原体菌株对这些药物产生了耐药性。为了防止耐药性，可以考虑将植物性药物作为替代疗法。最近的研究表明，少数草药含有对抗特定病原体的活性成分。本研究的目的是基于体外微生物研究了解罗勒（圣罗勒）的抗念珠菌作用。本系统评价遵循系统评价和Meta分析报告规范（PRISMA）。截至2021年，从PubMed和Cochrane的电子数据库中收集文章。纳入了关于罗勒及其对念珠菌种类作用的抗菌研究。我们排除了临床试验、综述、摘要文章和干预性研究。所选的抗菌研究使用了罗勒提取物的各种植物化学成分，并通过抑菌圈（ZOI）测量抗念珠菌特性。所有研究都证明了罗勒具有有效的抗念珠菌特性，表明它可能作为一种有效且经济实惠的“辅助药物”与系统性和局部念珠菌感染的标准治疗一起使用。负责抗念珠菌活性的罗勒主要成分可能是丁香酚和芳樟醇。然而，这些成分的作用机制尚不清楚。进一步评估毒性、耐久性及其他方面并随后进行临床试验的研究对于探索罗勒在对抗口腔疾病方面的潜力是必要的。
