Shi Yuanwei, Tang Danting, Li Xiaoqi, Xie Xiaoli, Ye Yufu, Wang Lijuan
School of Clinical Medicine, Weifang Medical University, Weifang, China.
Central Laboratory, Linyi People's Hospital, Linyi, China.
Front Oncol. 2022 May 23;12:889034. doi: 10.3389/fonc.2022.889034. eCollection 2022.
The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities. In recent years, a large number of studies have described the expression and correlation of galectins in different tumors. Each member of the family plays a vital role in tumor growth, progression, angiogenesis, adhesion, and tumor immune escape. Studies on the roles of galectins in lymphoma have mainly involved galectin-1, -3, -7, and -9. The results suggest that galectins may become novel targets for precise tumor treatment. This article reviews current research progress regarding galectins in lymphoma and provides new ideas for exploring them as novel targets for treating lymphoma and other important medical issues.
半乳糖凝集素蛋白家族与含β-半乳糖苷的聚糖具有高亲和力。这些蛋白参与细胞生长与分化、细胞黏附、细胞信号转导、细胞凋亡及其他细胞活动。近年来，大量研究描述了半乳糖凝集素在不同肿瘤中的表达及相关性。该家族的每个成员在肿瘤生长、进展、血管生成、黏附及肿瘤免疫逃逸中都起着至关重要的作用。对半乳糖凝集素在淋巴瘤中作用的研究主要涉及半乳糖凝集素-1、-3、-7和-9。结果表明，半乳糖凝集素可能成为精准肿瘤治疗的新靶点。本文综述了目前关于半乳糖凝集素在淋巴瘤中的研究进展，并为将其作为治疗淋巴瘤的新靶点及其他重要医学问题的探索提供新思路。
