Vermeulen Jenske J M, Jansen Anne-Jet S, van de Sande Sam, Hartman Yvonne A W, Holewijn Suzanne, Reijnen Michel M P J, Thijssen Dick H J
Department of Surgery, Rijnstate, Arnhem, the Netherlands.
Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.
Curr Res Physiol. 2022 May 28;5:224-231. doi: 10.1016/j.crphys.2022.05.004. eCollection 2022.
Sympathetic stimulation of central arteries, such as coronary and carotid arteries, cause vasodilation in healthy subjects, but vasoconstriction in those with increased cardiovascular risk. This study compared vasoreactivity to sympathetic stimulation between abdominal aorta and carotid artery in healthy young individuals (young group, n = 20), in patients with abdominal aortic aneurysm (AAA group, n = 20) and in a healthy older group, age- and gender matched with AAA group (matched group, n = 18).
All subjects underwent cold pressor test, while performing concomitantly duplex ultrasound of abdominal aorta and carotid artery vasoreactivity. Observer-independent software was used to analyze and calculate magnitude and timing of maximum vasodilation or vasoconstriction. Pearson's correlation coefficient was calculated to investigate vasoreactivity between arteries.
Carotid artery reactivity [Interquartile range 25%, Interquartile range 75%] did not significantly differ between the young, matched and AAA group (3.5% [1.4, 4.7], 2.6% [2.0, 4.1] and 2.2% [-1.9, 3.7], respectively, p = 0.301). Abdominal aortic responsiveness demonstrated larger differences between young (4.9% [-0.2, 8.4]), matched (3.3% [-2.5, 4.4]) and individuals with AAA (0.5% [-3.9, 4.1], p = 0.059). Pooled analysis showed a significant correlation between carotid and abdominal aortic vasoreactivity (r = 0.444, p = 0.001). Subgroup analyses demonstrated significant correlation between both arteries in young (r = 0.636, p = 0.003), but not matched (r = -0.040, p = 0.866) or AAA group (r = 0.410, p = 0.129).
Sympathetic stimulation induces powerful vasodilation of the carotid artery and abdominal aorta, which is significantly correlated in healthy individuals. No such correlation is present in abdominal aortic aneurysm patients. This suggests the aneurysm alters local abdominal aorta vasoreactivity, but not the carotid artery.
对冠状动脉和颈动脉等中心动脉的交感神经刺激，在健康受试者中会引起血管舒张，但在心血管风险增加的人群中会导致血管收缩。本研究比较了健康年轻个体（年轻组，n = 20）、腹主动脉瘤患者（AAA组，n = 20）以及年龄和性别与AAA组匹配的健康老年组（匹配组，n = 18）的腹主动脉和颈动脉对交感神经刺激的血管反应性。
所有受试者均接受冷加压试验，同时对腹主动脉和颈动脉的血管反应性进行双功超声检查。使用独立于观察者的软件分析并计算最大血管舒张或血管收缩的幅度和时间。计算Pearson相关系数以研究动脉之间的血管反应性。
年轻组、匹配组和AAA组之间的颈动脉反应性[四分位间距25%，四分位间距75%]无显著差异（分别为3.5%[1.4, 4.7]、2.6%[2.0, 4.1]和2.2%[-1.九, 3.7]，p = 0.301）。腹主动脉反应性在年轻组（4.9%[-0.2, 8.4]）、匹配组（3.3%[-2.5, 4.4]）和AAA患者（0.5%[-3.9, 4.1]）之间显示出较大差异（p = 0.059）。汇总分析显示颈动脉和腹主动脉血管反应性之间存在显著相关性（r = 0.444，p = 0.001）。亚组分析显示，年轻组中两条动脉之间存在显著相关性（r = 0.636，p = 0.003），但匹配组（r = -0.040，p = 0.866）或AAA组（r = 0.410，p = 0.129）中不存在。
交感神经刺激可引起颈动脉和腹主动脉的强力血管舒张，这在健康个体中显著相关。腹主动脉瘤患者中不存在这种相关性。这表明动脉瘤改变了腹主动脉局部的血管反应性，但未改变颈动脉的血管反应性。
