Zhang Guangheng, Lv Shimeng, Zhong Xia, Li Xiangyu, Yi Yunhao, Lu Yitong, Yan Wei, Li Jiamin, Teng Jing
Department of First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Pharmacol. 2024 Jan 8;14:1339057. doi: 10.3389/fphar.2023.1339057. eCollection 2023.
The incidence rate of depression, a mental disorder, is steadily increasing and has the potential to become a major global disability factor. Given the complex pathological mechanisms involved in depression, the use of conventional antidepressants may lead to severe complications due to their side effects. Hence, there is a critical need to explore the development of novel antidepressants. Ferroptosis, a newly recognized form of cell death, has been found to be closely linked to the onset of depression. Several studies have indicated that certain active ingredients can ameliorate depression by modulating the ferroptosis signaling pathway. Notably, traditional Chinese medicine (TCM) active ingredients and TCM prescriptions have demonstrated promising antidepressant effects in previous investigations owing to their unique advantages in antidepressant therapy. Building upon these findings, our objective was to review recent relevant research and provide new insights and directions for the development and application of innovative antidepressant strategies.
抑郁症作为一种精神障碍，其发病率正在稳步上升，并有成为全球主要致残因素的可能性。鉴于抑郁症涉及复杂的病理机制，使用传统抗抑郁药可能因其副作用而导致严重并发症。因此，迫切需要探索新型抗抑郁药的研发。铁死亡是一种新发现的细胞死亡形式，已被发现与抑郁症的发病密切相关。多项研究表明，某些活性成分可通过调节铁死亡信号通路来改善抑郁症。值得注意的是，中药活性成分和中药方剂在先前的研究中因其在抗抑郁治疗中的独特优势而显示出有前景的抗抑郁作用。基于这些发现，我们的目标是综述近期的相关研究，并为创新抗抑郁策略的开发和应用提供新的见解和方向。
