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清肺利痰汤对急性肺损伤/急性呼吸窘迫综合征的作用：抗炎和抗氧化作用的潜在机制

Qingfei Litan Decoction Against Acute Lung Injury/Acute Respiratory Distress Syndrome: The Potential Roles of Anti-Inflammatory and Anti-Oxidative Effects.

作者信息

Diao Yirui, Ding Qi, Xu Gonghao, Li Yadong, Li Zhenqiu, Zhu Hanping, Zhu Wenxiang, Wang Peng, Shi Yuanyuan

机构信息

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.

Shenzhen Research Institute, Beijing University of Chinese Medicine, Shenzhen, China.

出版信息

Front Pharmacol. 2022 May 23;13:857502. doi: 10.3389/fphar.2022.857502. eCollection 2022.

DOI:10.3389/fphar.2022.857502
PMID:35677439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9168533/
Abstract

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an acute respiratory failure syndrome characterized by progressive arterial hypoxemia and dyspnea. Qingfei Litan (QFLT) decoction, as a classic prescription for the treatment of acute respiratory infections, is effective for the treatment of ALI/ARDS. In this study, the compounds, hub targets, and major pathways of QFLT in ALI/ARDS treatment were analyzed using Ultra high performance liquid chromatography coupled with mass spectrometry (UHPLC-MS) and systemic pharmacology strategies. UHPLC-MS identified 47 main components of QFLT. To explore its anti-inflammatory and anti-oxidative mechanisms, gene ontology (Go) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment and network pharmacological analysis were conducted based on the main 47 components. KEGG enrichment analysis showed that TNF signaling pathway and Toll-like receptor signaling pathway may be the key pathways of ALI/ARDS. We explored the anti-inflammatory and anti-oxidative pharmacological effects of QFLT in treatment of ALI/ARDS and . QFLT suppressed the levels of proinflammatory cytokines and alleviated oxidative stress in LPS-challenged mice. , QFLT decreased the levels of TNF-α, IL-6, IL-1β secreted by LPS-activated macrophages, increased GSH level and decreased the LPS-activated reactive oxygen species (ROS) in lung epithelial A549 cells. This study suggested that QFLT may have anti-inflammatory and anti-oxidative effects on ALI/ARDS, combining and experiments with systemic pharmacology, providing a potential therapeutic strategy option.

摘要

急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）是一种以进行性动脉血氧不足和呼吸困难为特征的急性呼吸衰竭综合征。清肺利痰（QFLT）汤作为治疗急性呼吸道感染的经典方剂，对ALI/ARDS的治疗有效。在本研究中，采用超高效液相色谱-质谱联用（UHPLC-MS）和系统药理学策略分析了QFLT在ALI/ARDS治疗中的化合物、核心靶点和主要通路。UHPLC-MS鉴定出QFLT的47种主要成分。为探究其抗炎和抗氧化机制，基于这47种主要成分进行了基因本体（Go）分析、京都基因与基因组百科全书（KEGG）富集分析和网络药理学分析。KEGG富集分析表明，肿瘤坏死因子信号通路和Toll样受体信号通路可能是ALI/ARDS的关键通路。我们探究了QFLT在ALI/ARDS治疗中的抗炎和抗氧化药理作用。QFLT可抑制促炎细胞因子水平，并减轻脂多糖攻击小鼠的氧化应激。此外，QFLT可降低脂多糖激活的巨噬细胞分泌的肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1β水平，提高肺上皮A549细胞中谷胱甘肽水平，并降低脂多糖激活的活性氧（ROS）水平。本研究表明，QFLT可能对ALI/ARDS具有抗炎和抗氧化作用，将实验与系统药理学相结合，提供了一种潜在的治疗策略选择。

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