Hou Ting-Ting, Cai Yi, Zhang Zhen-Yu, Wang Cai-Yun, Tang Ying-Hao, Zhu Ming-Qiang, Wang Ya-Long
Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China.
Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
Front Chem. 2022 May 23;10:903253. doi: 10.3389/fchem.2022.903253. eCollection 2022.
As one of the typical fluorescent cores, dicyanomethylene-4H-pyran (DCM) derivatives exhibit excellent photophysical and photochemical properties, such as large Stokes shift, excellent light stability, and tunable near-infrared (NIR) emission. The luminescence mechanism of DCM probes mainly depends on the intramolecular charge transfer (ICT). Hence, by regulating the ICT process, the probes can specifically act on the target molecule. Accordingly, a series of NIR DCM probes have been constructed to detect the ions, reactive oxygen species (ROS), and biological macromolecules in cells. However, there is no relevant review to summarize it at present. This minireview mainly summarizes the NIR DCM probes based on ICT effect and their applications in biosensors and biological imaging in recent years. This will be beneficial to innovatively construct new DCM probes and actively promote their application in the future.
作为典型的荧光核之一，二氰基亚甲基-4H-吡喃（DCM）衍生物具有优异的光物理和光化学性质，如大斯托克斯位移、出色的光稳定性和可调谐近红外（NIR）发射。DCM探针的发光机制主要取决于分子内电荷转移（ICT）。因此，通过调节ICT过程，探针可以特异性地作用于目标分子。相应地，已经构建了一系列近红外DCM探针来检测细胞中的离子、活性氧（ROS）和生物大分子。然而，目前尚无相关综述对其进行总结。本综述主要总结了近年来基于ICT效应的近红外DCM探针及其在生物传感器和生物成像中的应用。这将有利于创新性地构建新型DCM探针，并在未来积极推动其应用。
