Rotar Oxana, Boyarinova Maria, Moguchaya Ekaterina, Tolkunova Kristina, Kolosov Nikita, Rezapova Valeriia, Freylikhman Olga, Usoltsev Dmitrii, Melnik Olesya, Sergushichev Alexey, Solntsev Vladislav, Kostareva Anna, Dubinina Elena, Voortman Trudy, Stevens Christine, Daly Mark J, Konradi Alexandra, Shlyakhto Evgeny, Artomov Mykyta
Almazov National Medical Research Centre, Saint Petersburg, Russia.
ITMO University, Saint Petersburg, Russia.
Front Cardiovasc Med. 2022 May 23;9:843439. doi: 10.3389/fcvm.2022.843439. eCollection 2022.
Age-related changes in the vascular system play an important role in the biological age and lifespan of a person and maybe affected from an early age onward. One of the indicators of changes in the vascular system is arterial wall stiffness and its main measure, i.e., carotid-femoral pulse wave velocity (cfPWV). We examined arterial wall stiffness in a sample of 305 Leningrad Siege survivors to assess how hunger and stressful conditions during fetal development and early childhood affected the state of the cardiovascular system at a later age and what factors may neutralize the negative impact sustained in early childhood. Here, we presented an evaluation of two unique patients with supernormal vascular aging (SUPERNOVA) phenotype from this cohort and described the details of congruence between hereditary resistance and practiced lifestyle yielding slower biological aging rate.
血管系统的年龄相关变化在人的生物学年龄和寿命中起着重要作用，并且可能从早年就受到影响。血管系统变化的指标之一是动脉壁硬度及其主要测量指标，即颈股脉搏波速度（cfPWV）。我们在305名列宁格勒围城战幸存者样本中检查了动脉壁硬度，以评估胎儿发育和幼儿期的饥饿及压力状况如何影响晚年的心血管系统状态，以及哪些因素可能抵消幼儿期遭受的负面影响。在此，我们展示了对该队列中两名具有超常血管衰老（SUPERNOVA）表型的独特患者的评估，并描述了遗传抗性与实践生活方式之间一致性的细节，这种一致性导致生物衰老速率较慢。
