Fortune D G, Ravnkilde V, Ryan S, Ramsay B, Clough S, Richards H L
Department of Psychology University of Limerick Limerick Republic of Ireland.
Charles Centre for Dermatology University Hospital Limerick Dooradoyle Republic of Ireland.
Skin Health Dis. 2022 Apr 5;2(2):e103. doi: 10.1002/ski2.103. eCollection 2022 Jun.
Despite the psychosocial challenges of living with psoriasis many patients may not be able to access appropriate services to manage these challenges. Mobile health interventions may be helpful as a means to support patients in managing the impact of their condition.
To conduct a preliminary examination of the feasibility and acceptability of a bespoke psoriasis-specific digital therapeutic solution (hereafter termed ), and to provide initial data on psychological changes pre-post.
Phase one proof of concept pre-post study. Eligible patients were provided with on their smartphone and assessed at baseline and at 12 weeks on a range of indices of well-being. Participants experiences on usability were collected by telephone interview at 4 weeks, 8 and 12 weeks.
Out of 66 participants recruited, 59 persisted in using Allay after the familiarisation phase, and 34 participants completed the 12 weeks programme. Participants showed a statistically significant improvement between induction and the end of the 12 weeks programme on Quality of life, Resilience, Perceptions of 'Overall impact' of psoriasis, and 'Emotional impact'. There was a significant change over the course of using Allay for symptoms of depression but not anxiety. While there was an interaction effect of changes in severity of psoriasis symptoms over the course of the study for dermatology-specific measures, there was no interaction between such changes in psoriasis symptoms and changes in depression, resilience or beliefs in emotional impact.
Study results suggest that the use of Allay as an adjunct to medical management of psoriasis may help patients improve resilience, mood, beliefs about their condition and enhance their quality of life. Given that this is a phase one proof of concept study, and our rates of attrition further research is necessary to examine comparative effectiveness and stability of these findings.
尽管银屑病患者在生活中面临心理社会挑战，但许多患者可能无法获得适当的服务来应对这些挑战。移动健康干预措施可能有助于支持患者应对病情的影响。
对定制的银屑病特异性数字治疗解决方案（以下简称“Allay”）的可行性和可接受性进行初步检查，并提供治疗前后心理变化的初始数据。
第一阶段概念验证前后对照研究。符合条件的患者在智能手机上安装Allay，并在基线和12周时就一系列幸福感指标进行评估。在第4周、第8周和第12周通过电话访谈收集参与者对可用性的体验。
在招募的66名参与者中，59名在熟悉阶段后继续使用Allay，34名参与者完成了12周的项目。参与者在诱导期和12周项目结束时，在生活质量、恢复力、对银屑病“总体影响”的认知以及“情绪影响”方面有统计学意义的改善。使用Allay治疗抑郁症症状有显著变化，但焦虑症状没有变化。虽然在研究过程中，银屑病症状严重程度的变化对皮肤病学特定指标有交互作用，但银屑病症状的这种变化与抑郁症、恢复力或情绪影响信念的变化之间没有交互作用。
研究结果表明，将Allay用作银屑病药物治疗的辅助手段可能有助于患者提高恢复力、改善情绪、改变对自身病情的信念并提高生活质量。鉴于这是一项第一阶段概念验证研究，且我们有损耗率，因此有必要进行进一步研究以检验这些发现的比较有效性和稳定性。
