• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

神经解剖结构对经颅磁刺激和间歇性经颅磁刺激期间及之后皮质运动兴奋性的影响。

Effect of neuroanatomy on corticomotor excitability during and after transcranial magnetic stimulation and intermittent theta burst stimulation.

机构信息

Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.

College of Engineering, Virginia Commonwealth University, Richmond, Virginia, USA.

出版信息

Hum Brain Mapp. 2022 Oct 1;43(14):4492-4507. doi: 10.1002/hbm.25968. Epub 2022 Jun 9.

DOI:10.1002/hbm.25968
PMID:35678552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9435000/
Abstract

Individual neuroanatomy can influence motor responses to transcranial magnetic stimulation (TMS) and corticomotor excitability after intermittent theta burst stimulation (iTBS). The purpose of this study was to examine the relationship between individual neuroanatomy and both TMS response measured using resting motor threshold (RMT) and iTBS measured using motor evoked potentials (MEPs) targeting the biceps brachii and first dorsal interosseus (FDI). Ten nonimpaired individuals completed sham-controlled iTBS sessions and underwent MRI, from which anatomically accurate head models were generated. Neuroanatomical parameters established through fiber tractography were fiber tract surface area (FTSA), tract fiber count (TFC), and brain scalp distance (BSD) at the point of stimulation. Cortical magnetic field induced electric field strength (EFS) was obtained using finite element simulations. A linear mixed effects model was used to assess effects of these parameters on RMT and iTBS (post-iTBS MEPs). FDI RMT was dependent on interactions between EFS and both FTSA and TFC. Biceps RMT was dependent on interactions between EFS and and both FTSA and BSD. There was no groupwide effect of iTBS on the FDI but individual changes in corticomotor excitability scaled with RMT, EFS, BSD, and FTSA. iTBS targeting the biceps was facilitatory, and dependent on FTSA and TFC. MRI-based measures of neuroanatomy highlight how individual anatomy affects motor system responses to different TMS paradigms and may be useful for selecting appropriate motor targets when designing TMS based therapies.

摘要

个体神经解剖结构可能会影响经颅磁刺激（TMS）的运动反应和间歇 theta 爆发刺激（iTBS）后的皮质运动兴奋性。本研究的目的是研究个体神经解剖结构与 TMS 反应（使用静息运动阈值（RMT）测量）和 iTBS 反应（使用针对肱二头肌和第一背骨间肌（FDI）的运动诱发电位（MEPs）测量）之间的关系。10 名非受损个体完成了假刺激控制 iTBS 疗程，并进行了 MRI 检查，从中生成了解剖准确的头部模型。通过纤维束追踪确定的神经解剖学参数包括纤维束表面积（FTSA）、束纤维计数（TFC）和刺激点的脑头皮距离（BSD）。使用有限元模拟获得皮质磁场诱导电场强度（EFS）。线性混合效应模型用于评估这些参数对 RMT 和 iTBS（iTBS 后 MEPs）的影响。FDI 的 RMT 取决于 EFS 与 FTSA 和 TFC 之间的相互作用。肱二头肌的 RMT 取决于 EFS 与 FTSA 和 BSD 之间的相互作用。iTBS 对 FDI 没有全组效应，但皮质运动兴奋性的个体变化与 RMT、EFS、BSD 和 FTSA 成正比。针对肱二头肌的 iTBS 具有易化作用，并且取决于 FTSA 和 TFC。基于 MRI 的神经解剖学测量突出了个体解剖结构如何影响不同 TMS 范式对运动系统的反应，并且在设计基于 TMS 的治疗时可能有助于选择合适的运动靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/730144bf3b69/HBM-43-4492-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/0a296d131f72/HBM-43-4492-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/1a4f2f59b0c4/HBM-43-4492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/9a3191a3d25c/HBM-43-4492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/400fa46c9980/HBM-43-4492-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/a1664bf42075/HBM-43-4492-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/cb5e5da2d7a0/HBM-43-4492-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/98879e39e851/HBM-43-4492-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/06af6d533dfe/HBM-43-4492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/172b44236ccf/HBM-43-4492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/143dce005bdc/HBM-43-4492-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/deab66cca713/HBM-43-4492-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/730144bf3b69/HBM-43-4492-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/0a296d131f72/HBM-43-4492-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/1a4f2f59b0c4/HBM-43-4492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/9a3191a3d25c/HBM-43-4492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/400fa46c9980/HBM-43-4492-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/a1664bf42075/HBM-43-4492-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/cb5e5da2d7a0/HBM-43-4492-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/98879e39e851/HBM-43-4492-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/06af6d533dfe/HBM-43-4492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/172b44236ccf/HBM-43-4492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/143dce005bdc/HBM-43-4492-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/deab66cca713/HBM-43-4492-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ae/9435000/730144bf3b69/HBM-43-4492-g012.jpg

相似文献

1
Effect of neuroanatomy on corticomotor excitability during and after transcranial magnetic stimulation and intermittent theta burst stimulation.神经解剖结构对经颅磁刺激和间歇性经颅磁刺激期间及之后皮质运动兴奋性的影响。
Hum Brain Mapp. 2022 Oct 1;43(14):4492-4507. doi: 10.1002/hbm.25968. Epub 2022 Jun 9.
2
The effect of intermittent theta burst stimulation on corticomotor excitability of the biceps brachii in nonimpaired individuals.间歇 theta 爆发刺激对非损伤个体肱二头肌皮质运动兴奋性的影响。
Neurosci Lett. 2021 Nov 1;764:136220. doi: 10.1016/j.neulet.2021.136220. Epub 2021 Sep 6.
3
Intermittent theta burst stimulation modulates biceps brachii corticomotor excitability in individuals with tetraplegia.间歇性 theta 爆发刺激调节四肢瘫痪患者肱二头肌皮质运动兴奋性。
J Neuroeng Rehabil. 2022 Jul 17;19(1):73. doi: 10.1186/s12984-022-01049-9.
4
Aftereffects of Intermittent Theta-Burst Stimulation in Adjacent, Non-Target Muscles.相邻非靶肌肉间歇性 theta 爆发刺激的后效。
Neuroscience. 2019 Oct 15;418:157-165. doi: 10.1016/j.neuroscience.2019.08.043. Epub 2019 Aug 31.
5
Intermittent theta-burst stimulation induces correlated changes in cortical and corticospinal excitability in healthy older subjects.间歇性θ波爆发刺激可引起健康老年受试者皮质和皮质脊髓兴奋性的相关变化。
Clin Neurophysiol. 2017 Dec;128(12):2419-2427. doi: 10.1016/j.clinph.2017.08.034. Epub 2017 Sep 28.
6
Differences in brain structure and theta burst stimulation-induced plasticity implicate the corticomotor system in loss of function after musculoskeletal injury.骨骼肌肉损伤后功能丧失与皮质运动系统有关，其与大脑结构和 theta 爆发刺激诱导的可塑性存在差异。
J Neurophysiol. 2021 Apr 1;125(4):1006-1021. doi: 10.1152/jn.00689.2020. Epub 2021 Feb 17.
7
Probing changes in corticospinal excitability following theta burst stimulation of the human primary motor cortex.探究人类初级运动皮层经theta爆发刺激后皮质脊髓兴奋性的变化。
Clin Neurophysiol. 2016 Jan;127(1):740-747. doi: 10.1016/j.clinph.2015.06.014. Epub 2015 Jun 18.
8
Similar effect of intermittent theta burst and sham stimulation on corticospinal excitability: A 5-day repeated sessions study.经颅磁刺激重复治疗 5 天：间歇 theta 爆发刺激和假刺激对皮质脊髓兴奋性的相似影响。
Eur J Neurosci. 2018 Aug;48(4):1990-2000. doi: 10.1111/ejn.14077. Epub 2018 Aug 16.
9
The effect of pulse shape in theta-burst stimulation: Monophasic vs biphasic TMS.双相磁刺激与单相磁刺激中脉冲形状的影响。
Brain Stimul. 2023 Jul-Aug;16(4):1178-1185. doi: 10.1016/j.brs.2023.08.001. Epub 2023 Aug 4.
10
The effects of D-Cycloserine on corticospinal excitability after repeated spaced intermittent theta-burst transcranial magnetic stimulation: A randomized controlled trial in healthy individuals.重复间隔式 theta 爆发经颅磁刺激后 D-环丝氨酸对皮质脊髓兴奋性的影响：一项健康个体的随机对照试验。
Neuropsychopharmacology. 2023 Jul;48(8):1217-1224. doi: 10.1038/s41386-023-01575-7. Epub 2023 Apr 11.

引用本文的文献

1
Sensory Entrained TMS (seTMS) enhances motor cortex plasticity.感觉诱发性重复经颅磁刺激（seTMS）可增强运动皮质可塑性。
bioRxiv. 2025 Jul 27:2025.07.23.666433. doi: 10.1101/2025.07.23.666433.
2
Supplementary motor area enhanced hemodynamic responses to loading after inhibitory cTBS.辅助运动区在抑制性连续θ波重复刺激后增强了对负荷的血流动力学反应。
Sci Rep. 2025 Aug 1;15(1):28046. doi: 10.1038/s41598-025-14103-y.
3
Brain Age Prediction in Type II GM1 Gangliosidosis.II型GM1神经节苷脂沉积病的脑年龄预测

本文引用的文献

1
The effect of intermittent theta burst stimulation on corticomotor excitability of the biceps brachii in nonimpaired individuals.间歇 theta 爆发刺激对非损伤个体肱二头肌皮质运动兴奋性的影响。
Neurosci Lett. 2021 Nov 1;764:136220. doi: 10.1016/j.neulet.2021.136220. Epub 2021 Sep 6.
2
Corticolimbic Modulation via Intermittent Theta Burst Stimulation as a Novel Treatment for Functional Movement Disorder: A Proof-of-Concept Study.通过间歇性theta爆发刺激进行皮质边缘调制作为功能性运动障碍的一种新治疗方法：一项概念验证研究。
Brain Sci. 2021 Jun 15;11(6):791. doi: 10.3390/brainsci11060791.
3
Transcranial Magnetic Stimulation in Psychiatry: Is There a Need for Electric Field Standardization?
medRxiv. 2025 Apr 25:2025.04.23.25326206. doi: 10.1101/2025.04.23.25326206.
4
Deep Learning Cerebellar Magnetic Resonance Imaging Segmentation in Late-Onset GM2 Gangliosidosis: Implications for Phenotype.迟发性GM2神经节苷脂沉积症的深度学习小脑磁共振成像分割：对表型的影响
medRxiv. 2025 Apr 11:2025.04.08.25325262. doi: 10.1101/2025.04.08.25325262.
5
Retrospective assessment of clinical global impression of severity and change in GM1 gangliosidosis: a tool to score natural history data in rare disease cohorts.GM1神经节苷脂贮积症严重程度和变化的临床整体印象回顾性评估：一种对罕见病队列自然史数据进行评分的工具。
Orphanet J Rare Dis. 2025 Mar 14;20(1):125. doi: 10.1186/s13023-025-03614-6.
6
Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study.经颅电刺激和磁刺激中电场建模的效标测量：系统评价和大规模建模研究。
Neuroimage. 2023 Nov 1;281:120379. doi: 10.1016/j.neuroimage.2023.120379. Epub 2023 Sep 15.
7
Prolonged continuous theta burst stimulation increases motor corticospinal excitability and intracortical inhibition in patients with neuropathic pain: An exploratory, single-blinded, randomized controlled trial.经颅直流电刺激联合运动想象训练对脑卒中后偏瘫患者上肢运动功能的影响
Neurophysiol Clin. 2023 Aug;53(4):102894. doi: 10.1016/j.neucli.2023.102894. Epub 2023 Aug 31.
精神科中的经颅磁刺激：是否需要电场标准化？
Front Hum Neurosci. 2021 Mar 9;15:639640. doi: 10.3389/fnhum.2021.639640. eCollection 2021.
4
Efficacy of Active vs Sham Intermittent Theta Burst Transcranial Magnetic Stimulation for Patients With Bipolar Depression: A Randomized Clinical Trial.主动式与假刺激式间歇性 theta 爆发经颅磁刺激治疗双相抑郁患者的疗效：一项随机临床试验。
JAMA Netw Open. 2021 Mar 1;4(3):e210963. doi: 10.1001/jamanetworkopen.2021.0963.
5
Evidence for interhemispheric imbalance in stroke patients as revealed by combining transcranial magnetic stimulation and electroencephalography.经颅磁刺激与脑电图结合揭示脑卒中患者半球间失衡的证据。
Hum Brain Mapp. 2021 Apr 1;42(5):1343-1358. doi: 10.1002/hbm.25297. Epub 2021 Jan 13.
6
Customizing TMS Applications in Traumatic Brain Injury Using Neuroimaging.使用神经影像学定制创伤性脑损伤中的 TMS 应用。
J Head Trauma Rehabil. 2020 Nov-Dec;35(6):401-411. doi: 10.1097/HTR.0000000000000627.
7
Neuromodulatory Interventions for Traumatic Brain Injury.创伤性脑损伤的神经调节干预措施
J Head Trauma Rehabil. 2020 Nov-Dec;35(6):365-370. doi: 10.1097/HTR.0000000000000643.
8
Alertness fluctuations when performing a task modulate cortical evoked responses to transcranial magnetic stimulation.当执行任务时警觉性波动会调节经颅磁刺激的皮质诱发反应。
Neuroimage. 2020 Dec;223:117305. doi: 10.1016/j.neuroimage.2020.117305. Epub 2020 Aug 28.
9
Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression.利用脑成像改善经颅磁刺激治疗抑郁症的空间靶向性。
Biol Psychiatry. 2021 Nov 15;90(10):689-700. doi: 10.1016/j.biopsych.2020.05.033. Epub 2020 Jun 7.
10
Large-scale analysis of interindividual variability in theta-burst stimulation data: Results from the 'Big TMS Data Collaboration'.大规模分析经颅磁刺激数据中的个体间变异性：来自“大型 TMS 数据合作”的结果。
Brain Stimul. 2020 Sep-Oct;13(5):1476-1488. doi: 10.1016/j.brs.2020.07.018. Epub 2020 Aug 3.