Hao Ying, Wang Zhuang, Frimpong Francis, Chen Xingjuan
College of Sports, Northwest Normal University, Lanzhou 730070, China.
Institute of Medical Research, Northwestern Polytechnical University, Xi'an 710072, China.
Curr Issues Mol Biol. 2022 May 16;44(5):2217-2229. doi: 10.3390/cimb44050150.
The increased permeability of the lung microvascular endothelium is one critical initiation of acute lung injury (ALI). The disruption of vascular-endothelium integrity results in leakiness of the endothelial barrier and accumulation of protein-rich fluid in the alveoli. During ALI, increased endothelial-cell (EC) permeability is always companied by high frequency and amplitude of cytosolic Ca oscillations. Mechanistically, cytosolic calcium oscillations include calcium release from internal stores and calcium entry via channels located in the cell membrane. Recently, numerous publications have shown substantial evidence that calcium-permeable channels play an important role in maintaining the integrity of the endothelium barrier function of the vessel wall in ALI. These novel endothelial signaling pathways are future targets for the treatment of lung injury. This short review focuses on the up-to-date research and provide insight into the contribution of calcium influx via ion channels to the disruption of lung microvascular endothelial-barrier function during ALI.
肺微血管内皮细胞通透性增加是急性肺损伤（ALI）的一个关键起始因素。血管内皮完整性的破坏导致内皮屏障渗漏，富含蛋白质的液体在肺泡中积聚。在ALI期间，内皮细胞（EC）通透性增加总是伴随着细胞质钙振荡的高频和高幅度。从机制上讲，细胞质钙振荡包括从内部储存释放钙以及通过位于细胞膜上的通道进入钙。最近，大量出版物显示了充分的证据，表明钙通透性通道在维持ALI中血管壁内皮屏障功能的完整性方面发挥着重要作用。这些新的内皮信号通路是未来治疗肺损伤的靶点。这篇简短的综述重点关注最新研究，并深入探讨通过离子通道的钙内流对ALI期间肺微血管内皮屏障功能破坏的作用。
