Department of Psychiatry and Bio-behavioral Sciences, University of California, Los Angeles, 90024, Los Angeles, CA, United States.
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 760 Westwood Plaza 68-262B, 90024, Los Angeles, CA, United States.
J Autism Dev Disord. 2023 Aug;53(8):3023-3033. doi: 10.1007/s10803-022-05616-w. Epub 2022 Jun 9.
Addressing factors that make it more likely for families to attrite from early intervention trials will allow researchers to ensure that families reap the full benefits of participation. This study was an analysis of 78 children (Mage = 18.38 months, SD = 5.78) at risk for autism participating in a university-based randomized controlled trial of two 8-week long early intervention programs. Overall, attrition through 8-weeks was low, approximately 13%, however by the one-year follow-up attrition rates were approximately 50%. The most consistent predictor of attrition was the distance that families had to travel to the university. These data highlight the importance of providing services and support (e.g., financial and logistic) during follow-up to families to maximize their participation. Clincaltrials.gov Identifier: NCT01874327, 6/11/2013.
解决使家庭更有可能退出早期干预试验的因素，将使研究人员能够确保家庭充分受益于参与。本研究分析了 78 名（平均年龄= 18.38 个月，标准差= 5.78）有自闭症风险的儿童，他们参加了一项基于大学的、两种为期 8 周的早期干预方案的随机对照试验。总体而言，通过 8 周的时间流失率较低，约为 13%，但在一年的随访中，流失率约为 50%。最一致的流失预测因素是家庭到大学的距离。这些数据强调了在随访期间为家庭提供服务和支持（例如财务和后勤支持）的重要性，以最大限度地提高他们的参与度。Clincaltrials.gov 标识符：NCT01874327，2013 年 6 月 11 日。
