纤维组织对左心房局灶性心律失常期间的电激活模式影响很小。
Fiber Organization has Little Effect on Electrical Activation Patterns during Focal Arrhythmias in the Left Atrium.
作者信息
He Jiyue, Pertsov Arkady M, Cherry Elizabeth M, Fenton Flavio H, Roney Caroline H, Niederer Steven A, Zang Zirui, Mangharam Rahul
机构信息
Department of Electrical and Systems Engineering, University of Pennsylvania, USA.
Department of Pharmacology, Upstate Medical University, USA.
出版信息
ArXiv. 2023 Apr 22:arXiv:2210.16497v3.
Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in clinical practice due to limited availability of tissue and cellular scale data. One such limitation is obtaining information about myocardial fiber organization in the clinical setting. In this study, we investigated a chimeric model of the left atrium utilizing clinically derived patient-specific atrial geometry and a realistic, yet foreign for a given patient fiber organization. We discovered that even significant variability of fiber organization had a relatively small effect on the spatio-temporal activation pattern during regular pacing. For a given pacing site, the activation maps were very similar across all fiber organizations tested.
在过去二十年中，心脏传导的逼真模型的发展呈现出一种稳定趋势，其细节程度不断提高。然而，由于组织和细胞尺度数据的可用性有限，使模型更加逼真会使其个性化以及在临床实践中的应用变得复杂。其中一个限制就是在临床环境中获取有关心肌纤维组织的信息。在本研究中，我们利用临床获取的患者特异性心房几何形状以及对于特定患者而言逼真但却是外来的纤维组织，研究了左心房的嵌合模型。我们发现，即使纤维组织存在显著变异性，在常规起搏期间对时空激活模式的影响也相对较小。对于给定的起搏部位，在所有测试的纤维组织中激活图都非常相似。
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