Tyler Shannyn A, Mersing David, Fenton Flavio H, Tinsley Mark R, Showalter Kenneth
Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
School of Physics, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Chaos. 2024 Sep 1;34(9). doi: 10.1063/5.0216649.
Cardiac arrythmias are a form of heart disease that contributes toward making heart disease a significant cause of death globally. Irregular rhythms associated with cardiac arrythmias are thought to arise due to singularities in the heart tissue that generate reentrant waves in the underlying excitable medium. A normal approach to removing such singularities is to apply a high voltage electric shock, which effectively resets the phase of the cardiac cells. A concern with the use of this defibrillation technique is that the high-energy shock can cause lasting damage to the heart tissue. Various theoretical works have investigated lower-energy alternatives to defibrillation. In this work, we demonstrate the effectiveness of a low-energy defibrillation method in an experimental 2D Belousov-Zhabotinsky (BZ) system. When implemented as a 2D spatial reaction, the BZ reaction serves as an effective analog of general excitable media and supports regular and reentrant wave activity. The defibrillation technique employed involves targeted low-energy perturbations that can be used to "teleport" and/or annihilate singularities present in the excitable BZ medium.
心律失常是心脏病的一种形式,它使心脏病成为全球范围内一个重要的死亡原因。与心律失常相关的不规则节律被认为是由于心脏组织中的奇点产生的,这些奇点在潜在的可兴奋介质中产生折返波。消除此类奇点的常规方法是施加高压电击,这能有效重置心脏细胞的相位。使用这种除颤技术的一个问题是高能电击会对心脏组织造成持久损伤。各种理论研究探讨了能量较低的除颤替代方法。在这项工作中,我们在实验性二维贝洛索夫 - 扎博廷斯基(BZ)系统中证明了一种低能量除颤方法的有效性。当作为二维空间反应实施时,BZ反应可作为一般可兴奋介质的有效模拟,并支持规则和折返波活动。所采用的除颤技术涉及有针对性的低能量扰动,可用于“传送”和/或消除可兴奋BZ介质中存在的奇点。