Kretschmer Matthias, Damoo Djihane, Sun Sherry, Lee Christopher W J, Croll Daniel, Brumer Harry, Kronstad James
Michael Smith Laboratories and Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Laboratory of Evolutionary Genetics, Institute of Biology, Université de Neuchâtel, Neuchâtel, Switzerland.
Science. 2022 Jun 10;376(6598):1187-1191. doi: 10.1126/science.abo2401. Epub 2022 Jun 9.
Many plant-associated fungi are obligate biotrophs that depend on living hosts to proliferate. However, little is known about the molecular basis of the biotrophic lifestyle, despite the impact of fungi on the environment and food security. In this work, we show that combinations of organic acids and glucose trigger phenotypes that are associated with the late stage of biotrophy for the maize pathogen . These phenotypes include the expression of a set of effectors normally observed only during biotrophic development, as well as the formation of melanin associated with sporulation in plant tumors. and other hemibiotrophic fungi also respond to a combination of carbon sources with enhanced proliferation. Thus, the response to combinations of nutrients from the host may be a conserved feature of fungal biotrophy.
许多与植物相关的真菌是专性生物营养型，依赖活的宿主进行增殖。然而，尽管真菌对环境和粮食安全有影响，但对于这种生物营养型生活方式的分子基础却知之甚少。在这项研究中，我们发现有机酸和葡萄糖的组合会引发与玉米病原体生物营养后期相关的表型。这些表型包括一组通常仅在生物营养发育过程中观察到的效应子的表达，以及与植物肿瘤中孢子形成相关的黑色素的形成。 以及其他半活体营养型真菌也会对碳源组合做出反应，增殖增强。因此，对宿主营养物质组合的反应可能是真菌生物营养的一个保守特征。
