University of California Davis, Department of Physiology & Membrane Biology, Davis CA, 95616, USA.
University of California Davis, Department of Physiology & Membrane Biology, Davis CA, 95616, USA.
Curr Opin Neurobiol. 2022 Aug;75:102571. doi: 10.1016/j.conb.2022.102571. Epub 2022 Jun 6.
Cold sensation is initiated in the periphery by a specialized population of cold-sensitive neurons, referred to as cold receptors, who transmit decreases in temperature with sub-degree resolution using a diverse assortment of ion channels and receptors. It is largely accepted that normal cold signaling is initiated through activation of transient receptor potential melastatin 8 (TRPM8) expressing neurons. Conversely, the mechanisms underlying cold-induced pain signaling are not as well defined. Interestingly, mounting evidence demonstrates functional interplay between cold signaling and other somatic sensations, such as itch and warmth; thus, cold-sensing pathways also engage in sensory crosstalk and population coding mechanisms. In this review, we will discuss recent advances in our understanding of cold sensation and address major gaps in knowledge that require more investigation.
冷觉是由一种被称为冷感受器的专门的冷敏神经元在周围发起的，它们使用各种不同的离子通道和受体来传递亚摄氏度分辨率的温度下降。人们普遍认为，正常的冷信号是通过激活表达瞬时受体电位 melastatin 8（TRPM8）的神经元来启动的。相反，冷诱导疼痛信号的机制还没有得到很好的定义。有趣的是，越来越多的证据表明冷信号与其他躯体感觉（如瘙痒和温暖）之间存在功能相互作用；因此，冷感觉通路也参与了感觉串扰和群体编码机制。在这篇综述中，我们将讨论我们对冷觉的理解的最新进展，并讨论需要进一步研究的主要知识空白。
