State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu Province, China.
BGI Genomics, BGI-Shenzhen, Shenzhen 518083, China.
Gene. 2022 Aug 5;834:146650. doi: 10.1016/j.gene.2022.146650. Epub 2022 Jun 6.
Taenia pisiformis is one of the most widespread gastrointestinal parasites and its larvae (cysticercosis) causes significant economic loss to rabbit industry. No efficient drug is available for this disease to date. To better understand its genomics, we assembled a 211-Mb high quality genome of T. pisiformis at chromosome level with a scaffold N50 size of 20 Mbp. Totally, 12,097 protein-coding genes was predicted from the genome. Genome-level phylogenetic analysis confirmed the taxonomic affiliations with other tapeworms and revealed that T. pisiformis diverged from its closely related relative T. hydatigena ∼ 14.6 Mya. Comparative genomic analyses revealed that the T. pisiformis genome was characterized by adaptive features of strong positive selection signals from carbohydrate/lipid metabolism and body surface integrity, and of expanded gene families related to metabolism of amino acids and lipids. The high-quality genome of T. pisiformis constitutes a resource for the comparative genomics and for further applications in general parasitology.
豆状带绦虫是一种广泛分布的胃肠道寄生虫，其幼虫（囊尾蚴）给兔业造成了巨大的经济损失。迄今为止，尚无针对这种疾病的有效药物。为了更好地了解其基因组学，我们将豆状带绦虫的染色体水平基因组组装到 211Mb，支架 N50 大小为 20 Mbp。总共预测到了 12097 个蛋白质编码基因。基因组水平的系统发育分析证实了与其他绦虫的分类关系，并表明豆状带绦虫与亲缘关系密切的Hydatigera 绦虫大约在 1460 万年前就已经分化了。比较基因组分析表明，豆状带绦虫的基因组具有碳水化合物/脂质代谢和体表完整性的强烈正向选择信号的适应特征，以及与氨基酸和脂质代谢相关的基因家族的扩展。高质量的豆状带绦虫基因组为比较基因组学提供了资源，并为普通寄生虫学的进一步应用提供了资源。
