Habib N A, Wood C B, Apostolov K, Thompson A, Barker W, Mentha G, Coutilno J, Hershman M
Cancer Detect Prev. 1987;10(1-2):57-61.
Patients with liver neoplasms have a significantly lower stearic to oleic ratio (SI) in tumour (x = 0.36) vs non-tumour liver tissues (x = 0.75; P less than 0.001). The SI of circulating erythrocytes is lower in cancer patients (n = 100; X = 0.69) than noncancer patients (n = 50; x = 1.45) and normal subjects (n = 50; x = 1.5) (p less than 0.001). It was also found that urine protein extracts from cancer patients reduce the SI of cultured cell membrane (n = 10; x = 0.74) as compared to urine from noncancer patients (n = 10; x = 1.02; p less than 0.001). This study suggests that patients with cancer release a desaturation-producing factor from the malignant cells into the systemic circulation and subsequently into the urine. The observed increased unsaturation (oleic acid) in the circulating erythrocytes can be useful in the diagnosis and postoperative monitoring of cancer patients.
与非肿瘤肝脏组织（x = 0.75；P < 0.001）相比，肝脏肿瘤患者肿瘤组织中的硬脂酸与油酸比值（SI）显著更低（x = 0.36）。癌症患者（n = 100；X = 0.69）循环红细胞的SI低于非癌症患者（n = 50；x = 1.45）和正常受试者（n = 50；x = 1.5）（p < 0.001）。还发现，与非癌症患者尿液（n = 10；x = 1.02；p < 0.001）相比，癌症患者的尿蛋白提取物可降低培养细胞膜的SI（n = 10；x = 0.74）。这项研究表明，癌症患者会从恶性细胞释放一种产生去饱和作用的因子进入体循环，随后进入尿液。循环红细胞中观察到的不饱和脂肪酸（油酸）增加可能有助于癌症患者的诊断和术后监测。
