炎症小体在心房颤动中的作用：美国心脏病学会的最新综述
Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review.
机构信息
Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai, China.
Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada; Research Center, Montreal Heart Institute, Montreal, Quebec, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada; Institute of Pharmacology, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany; IHU LIYRC Institute, Bordeaux, France.
出版信息
J Am Coll Cardiol. 2022 Jun 14;79(23):2349-2366. doi: 10.1016/j.jacc.2022.03.379.
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in patients with cardiovascular diseases. Despite the multifaceted nature of AF pathogenesis and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3 inflammasome activation contributes to onset and progression of AF. Herein, the authors aim at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis, and novel therapeutic options in the management of AF.
作为最常见的心律失常形式，心房颤动（AF）增加了心力衰竭、血栓栓塞和中风的风险，导致心血管疾病患者的死亡率和发病率上升。尽管 AF 发病机制具有多方面的性质和 AF 病理生理学的复杂性，但越来越多的证据表明 NLRP3 炎性小体的激活有助于 AF 的发生和发展。本文作者旨在综述炎性小体信号在 AF 发病机制中的作用以及 AF 治疗的新方法。
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