Gosav Evelina Maria, Tanase Daniela Maria, Ouatu Anca, Buliga-Finis Oana Nicoleta, Popescu Diana, Dascalu Cristina Gena, Dima Nicoleta, Badescu Minerva Codruta, Rezus Ciprian
Department of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Internal Medicine Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iasi, Romania.
Life (Basel). 2025 Jun 16;15(6):960. doi: 10.3390/life15060960.
Atrial fibrillation (AF) is one of the most common cardiac arrhythmias encountered globally, characterized by a pro-inflammatory pattern. This analysis evaluated the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with AF alongside chronic kidney disease (CKD) and/or type 2 diabetes mellitus (T2DM). This retrospective cohort study included 6077 patients admitted to the Third Medical Clinic of Saint Spiridon Hospital in Iasi from 2018 to 2023, all diagnosed with AF, CKD, and T2DM. After applying the exclusion criteria, 1066 AF patients remained eligible. For a multivariate comparative analysis, the patients were divided into groups: I. control group (non-AF patients); II. AF patients; III. T2DM group; IV. CKD-only group; V. AF+CKD group; VI. AF+T2DM group; and VII. AF+T2DM+CKD group. The Mann-Whitney/Kruskal-Wallis test demonstrated a statistically significant difference in NLR and PLR values between the AF group and the non-AF group (H = 70.627, < 0.001). The receiver operating characteristic (ROC) analysis identified statistical significance and predictive power for NLR (AUC = 0.722; sensitivity = 63.6%; specificity = 76.9%) and neutrophil count in diagnosing AF, T2DM, and CKD. In conclusion, this study illustrated the utility of NLR and PLR as readily available and predictive biomarkers of inflammation in patients with AF, with or without comorbidities.
心房颤动（AF）是全球最常见的心律失常之一，其特征为促炎模式。本分析评估了合并慢性肾脏病（CKD）和/或2型糖尿病（T2DM）的AF患者的中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）。这项回顾性队列研究纳入了2018年至2023年在雅西圣斯皮里东医院第三内科就诊的6077例患者，所有患者均被诊断为AF、CKD和T2DM。应用排除标准后，1066例AF患者仍符合条件。为进行多变量比较分析，将患者分为以下几组：I. 对照组（非AF患者）；II. AF患者；III. T2DM组；IV. 单纯CKD组；V. AF+CKD组；VI. AF+T2DM组；VII. AF+T2DM+CKD组。Mann-Whitney/Kruskal-Wallis检验显示，AF组和非AF组之间的NLR和PLR值存在统计学显著差异（H = 70.627，P < 0.001）。受试者工作特征（ROC）分析确定了NLR（AUC = 0.722；敏感性 = 63.6%；特异性 = 76.9%）和中性粒细胞计数在诊断AF、T2DM和CKD方面具有统计学意义和预测能力。总之，本研究说明了NLR和PLR作为AF患者（无论有无合并症）炎症的易于获得且具有预测性的生物标志物的实用性。
