Oktaria Vicka, Putri Dwi Astuti Dharma, Ihyauddin Zulfikar, Julia Madarina, Sulistyoningrum Dian Caturini, Koon Poh Bee, Danchin Margaret, Murni Indah Kartika
Department of Biostatistics, Epidemiology and Population Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Sleman, Daerah Istimewa Yogyakarta, Indonesia
Center for Child Health-Pediatric Research Office, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Sleman, Daerah Istimewa Yogyakarta, Indonesia.
Arch Dis Child. 2022 Oct 19;107(11):980-987. doi: 10.1136/archdischild-2021-323765.
To describe the prevalence and determinants of vitamin D deficiency (VDD) among healthy children aged between 0 and 18 years living in South-East Asia (SEA).
We systematically searched Ovid MEDLINE and Ovid EMBASE for observational studies assessing VDD among healthy children in the SEA region as the primary or secondary outcome from database inception to 6 April 2021. PubMed was used for e-pubs and publications not indexed in Medline. Publications that included abstracts in English were included. We performed a systematic review to describe the prevalence of VDD in SEA children.
Our initial search identified 550 publications with an additional 2 publications from manual screening. Of those, 21 studies from 5 different countries (Thailand, Indonesia, Vietnam, Malaysia and Cambodia) were summarised and included in forest plots. The prevalence of VDD (<50 nmol/L) ranged from 0.9% to 96.4%, with >50% of newborns having VDD, and severe VDD (<30 nmol/L) ranged from 0% to 55.8%. Female sex and urban living were the most common determinants of VDD.
VDD among healthy children living in the SEA region is common. Efforts to detect VDD and the implementation of preventive measures, including education on safe sun exposure and oral vitamin D supplementation or food fortification, should be considered for key target groups, including adolescent females and pregnant and lactating women to improve the vitamin D status of newborns.
This study is registered with PROSPERO (CRD42020181600).
描述东南亚地区0至18岁健康儿童维生素D缺乏症（VDD）的患病率及其决定因素。
我们系统检索了Ovid MEDLINE和Ovid EMBASE，以查找评估东南亚地区健康儿童VDD的观察性研究，将其作为从数据库建立至2021年4月6日的主要或次要结局。PubMed用于检索电子出版物和未被Medline索引的出版物。纳入了包含英文摘要的出版物。我们进行了一项系统评价，以描述东南亚儿童VDD的患病率。
我们最初的检索确定了550篇出版物，通过手工筛选又发现了2篇。其中，对来自5个不同国家（泰国、印度尼西亚、越南、马来西亚和柬埔寨）的21项研究进行了总结并纳入森林图分析。VDD（<50 nmol/L）的患病率在0.9%至96.4%之间，超过50%的新生儿存在VDD，严重VDD（<30 nmol/L）的患病率在0%至55.8%之间。女性和城市居住是VDD最常见的决定因素。
东南亚地区健康儿童中VDD很常见。应考虑对包括青春期女性、孕妇和哺乳期妇女在内的关键目标人群进行VDD检测，并采取预防措施，包括进行安全日晒教育以及口服维生素D补充剂或食品强化，以改善新生儿的维生素D状况。
本研究已在PROSPERO注册（CRD42020181600）。
