School of Nursing, College of Medicine, National Taiwan University, No. 1, Ren-Ai Rd. Sec. 1, Taipei 10051, Taiwan.
School of Nursing and Graduate Institute of Nursing, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung 40604, Taiwan.
Int J Environ Res Public Health. 2022 May 27;19(11):6537. doi: 10.3390/ijerph19116537.
Heart rate variability (HRV) is a powerful tool for observing interactions between the sympathetic and parasympathetic nervous systems. This study evaluated HRV during a mindfulness-based stress reduction (MBSR) program among women with breast cancer after receiving treatment. A quasi-experimental, nonrandomized design was used. Patients were allocated to usual care (n = 25) and MBSR (n = 25) groups. HRV was measured using recognized methods to assess the autonomic nervous system. Two-way ANOVA and t-tests were used to examine HRV changes between and within groups, respectively. A significant interaction effect of time with group was observed on heart rate (F (1, 96) = 4.92, p = 0.029, η2 = 0.049). A significant difference was also observed within the MBSR group preintervention and postintervention with regard to heart rate (t (24) = −3.80, p = 0.001), standard deviation of the RR interval (t (24) = 5.40, p < 0.001), root-mean-square difference in the RR interval (t (24) = 2.23, p = 0.035), and high-frequency power (t (24) = 7.73, p < 0.001). Large effect sizes for heart rate and SDNN of 0.94 and 0.85, respectively, were observed between the MBSR and usual care groups. This study provides preliminary evidence that an MBSR program may be clinically useful for facilitating parasympathetic activity associated with feelings of relaxation in treated breast cancer survivors.
心率变异性（HRV）是观察交感和副交感神经系统相互作用的有力工具。本研究评估了接受治疗后患有乳腺癌的女性在进行正念减压（MBSR）项目期间的 HRV。采用准实验、非随机设计。患者被分配到常规护理（n=25）和 MBSR（n=25）组。使用公认的方法测量 HRV 以评估自主神经系统。使用双向方差分析和 t 检验分别检验组间和组内 HRV 的变化。观察到心率的时间与组之间存在显著的交互效应（F（1，96）=4.92，p=0.029，η2=0.049）。MBSR 组在干预前后的心率也存在显著差异（t（24）=-3.80，p=0.001）、RR 间期标准差（t（24）=5.40，p<0.001）、RR 间期均方根差（t（24）=2.23，p=0.035）和高频功率（t（24）=7.73，p<0.001）。MBSR 组与常规护理组之间的心率和 SDNN 分别观察到 0.94 和 0.85 的大效应量。这项研究提供了初步证据，表明 MBSR 方案可能对促进治疗后乳腺癌幸存者与放松感相关的副交感神经活动具有临床意义。
