Martins Alexandre D, Brito João Paulo, Oliveira Rafael, Costa Tiago, Ramalho Fátima, Santos-Rocha Rita, Pimenta Nuno
Institute of Santarém, Sports Science School of Rio Maior-Polytechnic, 2140-413 Rio Maior, Portugal.
CIEQV-Life Quality Research Centre, Av. Dr. Mário Soares No. 110, 2040-413 Rio Maior, Portugal.
Healthcare (Basel). 2021 Sep 13;9(9):1205. doi: 10.3390/healthcare9091205.
Breast cancer is the most common malignancy among women worldwide. The treatments may also cause neuromuscular and skeletal disorders; therefore, the aim of this study was to verify the existence of a relationship between heart rate variability and different functional fitness parameters in women survivors of breast cancer.
This cross-sectional study included 25 women survivors of breast cancer, with a mean ± SD age, height, and body mass of 50.8 ± 8.8 years, 1.6 ± 0.7 m, and 67.1 ± 12.3 kg, respectively. Patients underwent measurements of heart rate variability with time and frequency domain analyses, as well as a "30 s chair-stand test", "6 min walking test", "timed up and go test", and "ball throwing test".
A multiple linear regression analysis showed that from the heart rate variability frequency domain, high frequency explained 21% (R = 0.21) of the "30 s chair-stand test" performance.
The findings of this study highlight high frequency as a predictor of "30 s chair-stand test" performance, regardless of age and time after diagnosis, suggesting its usefulness as a clinical indicator of functionality in breast cancer survivors. This study presents a straightforward and non-invasive methodology predicting functional fitness in women breast cancer survivors potentially applicable to clinical practice.
乳腺癌是全球女性中最常见的恶性肿瘤。其治疗方法也可能导致神经肌肉和骨骼疾病；因此，本研究的目的是验证乳腺癌女性幸存者心率变异性与不同功能适应性参数之间是否存在关联。
这项横断面研究纳入了25名乳腺癌女性幸存者，其平均年龄±标准差、身高和体重分别为50.8±8.8岁、1.6±0.7米和67.1±12.3千克。患者接受了心率变异性的时域和频域分析测量，以及“30秒坐立试验”、“6分钟步行试验”、“计时起立行走试验”和“投球试验”。
多元线性回归分析表明，在心率变异性频域中，高频成分解释了“30秒坐立试验”表现的21%（R=0.21）。
本研究结果突出了高频作为“30秒坐立试验”表现预测指标的作用，无论年龄和诊断后的时间如何，表明其作为乳腺癌幸存者功能临床指标的有用性。本研究提出了一种简单且无创的方法来预测女性乳腺癌幸存者的功能适应性，可能适用于临床实践。
