Department of Functional Diagnostics and Physical Medicine, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland.
Department of Biochemical Sciences, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, Poland.
Int J Environ Res Public Health. 2022 May 27;19(11):6548. doi: 10.3390/ijerph19116548.
(1) Background: Of all environmental pollutants, heavy metals have the most detrimental effect on public health because they remain in the ecosystem and are not biodegradable. The neurotoxicity of heavy metals, including cadmium and lead, has been well documented, and blood levels of heavy metals serve as a biomarker of exposure, reflecting their content in soft tissues. Multiple sclerosis (MS) is one of the most common chronic neurodegenerative diseases. The pathogenesis of MS is complex and relies on the interaction between genetic and environmental factors. The aim of this study was to search for the relationship between the values of cadmium and lead concentration in the blood and the health history and functional status of patients with MS. (2) Methods: The study group consisted of 151 patients with a clinical diagnosis of MS. Determination of the presence of tested elements in serum was performed using an ELAN DRC-e ICP mass spectrometer. (3) Results: Statistical analysis demonstrated that an increase in the level of cadmium was accompanied by an increase in the level of lead. There was no significant correlation between the blood lead concentration and the functional status assessed by EDSS among patients with MS in Poland. However, a tendency towards worse functional status of patients with higher blood lead concentration ( = 0.07) was demonstrated. Patients who experienced first MS symptoms at older age had higher blood levels of the tested metals. (4) Conclusions: The concentrations of cadmium and lead in the blood of MS patients in Poland were not factors differentiating their functional status and the course of the disease.
(1) 背景：在所有环境污染物中，重金属对公众健康的危害最大，因为它们在生态系统中停留并不能生物降解。重金属（包括镉和铅）的神经毒性已有充分的记录，而重金属的血液水平则作为暴露的生物标志物，反映其在软组织中的含量。多发性硬化症（MS）是最常见的慢性神经退行性疾病之一。MS 的发病机制复杂，依赖于遗传和环境因素的相互作用。本研究旨在寻找血液中镉和铅浓度值与 MS 患者的健康史和功能状态之间的关系。(2) 方法：研究组由 151 名临床诊断为 MS 的患者组成。使用 ELAN DRC-e ICP 质谱仪测定血清中检测元素的存在。(3) 结果：统计分析表明，镉水平的升高伴随着铅水平的升高。在波兰的 MS 患者中，血铅浓度与 EDSS 评估的功能状态之间没有显著相关性。然而，在血铅浓度较高的患者中，其功能状态更差的趋势（=0.07）。首次出现 MS 症状年龄较大的患者血中检测金属的水平较高。(4) 结论：波兰 MS 患者的血液中镉和铅浓度不是区分其功能状态和疾病进程的因素。
