Department of Physics and Applied Mathematics, Universidad de Navarra, 31009 Pamplona, Spain.
School of Engineering, Universidad de La Sabana, Chía 25001, Colombia.
Int J Environ Res Public Health. 2022 Jun 6;19(11):6934. doi: 10.3390/ijerph19116934.
Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repetitive upper airway obstruction, intermittent hypoxemia, and recurrent awakenings during sleep. The most used treatment for this syndrome is a device that generates a positive airway pressure—Continuous Positive Airway Pressure (CPAP), but it works continuously, whether or not there is apnea. An alternative consists on systems that detect apnea episodes and produce a stimulus that eliminates them. Article focuses on the development of a simple and autonomous processing system for the detection of obstructive sleep apneas, using polysomnography (PSG) signals: electroencephalography (EEG), electromyography (EMG), respiratory effort (RE), respiratory flow (RF), and oxygen saturation (SO2). The system is evaluated using, as a gold standard, 20 PSG tests labeled by sleep experts and it performs two analyses. A first analysis detects awake/sleep stages and is based on the accumulated amplitude in a channel-dependent frequency range, according to the criteria of the American Academy of Sleep Medicine (AASM). The second analysis detects hypopneas and apneas, based on analysis of the breathing cycle and oxygen saturation. The results show a good estimation of sleep events, where for 75% of the cases of patients analyzed it is possible to determine the awake/asleep states with an effectiveness of >92% and apneas and hypopneas with an effectiveness of >55%, through a simple processing system that could be implemented in an electronic device to be used in possible OSA treatments.
阻塞性睡眠呼吸暂停(OSA)是一种常见的睡眠障碍,其特征是上呼吸道反复阻塞、间歇性低氧血症和睡眠中反复觉醒。该综合征最常用的治疗方法是一种产生正压气道的设备——持续气道正压通气(CPAP),但它持续工作,无论是否存在呼吸暂停。另一种方法是检测呼吸暂停事件并产生消除它们的刺激的系统。本文专注于开发一种简单且自主的处理系统,用于检测阻塞性睡眠呼吸暂停,使用多导睡眠图(PSG)信号:脑电图(EEG)、肌电图(EMG)、呼吸努力(RE)、呼吸流量(RF)和氧饱和度(SO2)。该系统使用经过睡眠专家标记的 20 个 PSG 测试作为金标准进行评估,并进行了两项分析。第一项分析检测清醒/睡眠阶段,基于根据美国睡眠医学学会(AASM)标准在通道相关频率范围内累积的幅度。第二项分析基于呼吸周期和氧饱和度分析检测呼吸暂停和低通气。结果表明,对睡眠事件进行了很好的估计,对于分析的 75%的患者病例,可以通过一个简单的处理系统,以>92%的有效性确定清醒/睡眠状态,以及以>55%的有效性确定呼吸暂停和低通气,该系统可以在电子设备中实现,用于可能的 OSA 治疗。