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核心技术专利：CN118964589B侵权必究
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食品添加剂氧化锌纳米颗粒：溶解、相互作用、归宿、细胞毒性和口服毒性。

Food Additive Zinc Oxide Nanoparticles: Dissolution, Interaction, Fate, Cytotoxicity, and Oral Toxicity.

机构信息

Division of Applied Food System, Major of Food Science & Technology, Seoul Women's University, Seoul 01797, Korea.

出版信息

Int J Mol Sci. 2022 May 28;23(11):6074. doi: 10.3390/ijms23116074.

DOI:10.3390/ijms23116074
PMID:35682753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9181433/
Abstract

Food additive zinc oxide (ZnO) nanoparticles (NPs) are widely used as a Zn supplement in the food and agriculture industries. However, ZnO NPs are directly added to complex food-matrices and orally taken through the gastrointestinal (GI) tract where diverse matrices are present. Hence, the dissolution properties, interactions with bio- or food-matrices, and the ionic/particle fates of ZnO NPs in foods and under physiological conditions can be critical factors to understand and predict the biological responses and oral toxicity of ZnO NPs. In this review, the solubility of ZnO NPs associated with their fate in foods and the GI fluids, the qualitative and quantitative determination on the interactions between ZnO NPs and bio- or food-matrices, the approaches for the fate determination of ZnO NPs, and the interaction effects on the cytotoxicity and oral toxicity of ZnO NPs are discussed. This information will be useful for a wide range of ZnO applications in the food industry at safe levels.

摘要

食品添加剂氧化锌（ZnO）纳米粒子（NPs）广泛用作食品和农业工业中的 Zn 补充剂。然而，ZnO NPs 直接添加到复杂的食物基质中，并通过胃肠道（GI）道被口服摄入，其中存在多种基质。因此，ZnO NPs 在食品中的溶解特性、与生物或食物基质的相互作用以及在生理条件下的离子/颗粒命运，可能是理解和预测 ZnO NPs 的生物反应和口服毒性的关键因素。在本综述中，讨论了与 ZnO NPs 在食品和 GI 液中的命运相关的溶解度、ZnO NPs 与生物或食物基质之间相互作用的定性和定量测定、ZnO NPs 命运测定的方法以及对 ZnO NPs 细胞毒性和口服毒性的相互作用效应。这些信息将有助于在食品工业中以安全水平广泛应用 ZnO。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/24ce5d27dfef/ijms-23-06074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/2df3d50f47f8/ijms-23-06074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/201e40c56bee/ijms-23-06074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/f6f611d0d15e/ijms-23-06074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/24ce5d27dfef/ijms-23-06074-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/2df3d50f47f8/ijms-23-06074-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/201e40c56bee/ijms-23-06074-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/f6f611d0d15e/ijms-23-06074-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/9181433/24ce5d27dfef/ijms-23-06074-g004.jpg

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Food Additive Zinc Oxide Nanoparticles: Dissolution, Interaction, Fate, Cytotoxicity, and Oral Toxicity.

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Zinc Oxide Nanoparticles as Next-Generation Feed Additives: Bridging Antimicrobial Efficacy, Growth Promotion, and Sustainable Strategies in Animal Nutrition.

Nanomaterials (Basel). 2025-7-2

[2]
Formation Mechanisms of Protein Coronas on Food-Related Nanoparticles: Their Impact on Digestive System and Bioactive Compound Delivery.

Foods. 2025-2-5

[3]
An Adverse Outcome Pathway for food nanomaterial-induced intestinal barrier disruption.

Front Toxicol. 2024-12-24

[4]
Durable Antimicrobial Microstructure Surface (DAMS) Enabled by 3D-Printing and ZnO Nanoflowers.

Langmuir. 2025-2-11

[5]
Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model.

Bioprocess Biosyst Eng. 2024-8

[6]
Combination of Hydrolysable Tannins and Zinc Oxide on Enterocyte Functionality: In Vitro Insights.

Biomolecules. 2024-6-6

[7]
Synthesis and Characterization of Naproxen Intercalated Zinc Oxide Stacked Nanosheets for Enhanced Hepatoprotective Potential.

ACS Omega. 2024-5-13

[8]
Impact of peripheral blood mononuclear cells preconditioned by activated platelet supernatant in managing gastric mucosal damage induced by zinc oxide nanoparticles in rats.

Anat Cell Biol. 2024-3-31

[9]
Development of new generation cakes fortified with zinc oxide nanoparticles.

J Food Sci Technol. 2024-2

[10]
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Nanoscale Adv. 2023-10-5

本文引用的文献

[1]
Toxic effects of zinc oxide nanoparticles combined with vitamin C and casein phosphopeptides on gastric epithelium cells and the intestinal absorption of mice.

RSC Adv. 2018-7-20

[2]
Dietary exposure of zinc oxide nanoparticles (ZnO-NPs) from canned seafood by single particle ICP-MS: Balancing of risks and benefits for human health.

Ecotoxicol Environ Saf. 2022-2

[3]
Interaction between ZnO Nanoparticles and Albumin and Its Effect on Cytotoxicity, Cellular Uptake, Intestinal Transport, Toxicokinetics, and Acute Oral Toxicity.

Nanomaterials (Basel). 2021-10-31

[4]
Solubility of ZnO Nanoparticles in Food Media: An Analysis Using a Novel Semiclosed Dynamic System.

J Agric Food Chem. 2021-9-22

[5]
Guidance on risk assessment of nanomaterials to be applied in the food and feed chain: human and animal health.

EFSA J. 2021-8-3

[6]
Role of structural specificity of ZnO particles in preserving functionality of proteins in their corona.

Sci Rep. 2021-8-5

[7]
Particle Size and Biological Fate of ZnO Do Not Cause Acute Toxicity, but Affect Toxicokinetics and Gene Expression Profiles in the Rat Livers after Oral Administration.

Int J Mol Sci. 2021-2-8

[8]
Efficacy of nano zinc oxide dietary supplements on growth performance, immunomodulation and disease resistance of African catfish Clarias gariepinus.

Dis Aquat Organ. 2020-12-17

[9]
Impact of bovine serum albumin - A protein corona on toxicity of ZnO NPs in environmental model systems of plant, bacteria, algae and crustaceans.

Chemosphere. 2021-5

[10]
The investigation of the parameters affecting the ZnO nanoparticle cytotoxicity behaviour: a tutorial review.

Biomater Sci. 2020-11-21

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