抗体在治疗 SARS-CoV-2 病毒感染中的作用，以及评估其对抗体依赖增强感染的贡献。

The Role of Antibodies in the Treatment of SARS-CoV-2 Virus Infection, and Evaluating Their Contribution to Antibody-Dependent Enhancement of Infection.

机构信息

Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose Street, Glasgow G1 1XJ, UK.

The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.

出版信息

Int J Mol Sci. 2022 May 28;23(11):6078. doi: 10.3390/ijms23116078.

DOI:10.3390/ijms23116078

PMID:35682757

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9181534/

Abstract

Antibodies play a crucial role in the immune response, in fighting off pathogens as well as helping create strong immunological memory. Antibody-dependent enhancement (ADE) occurs when non-neutralising antibodies recognise and bind to a pathogen, but are unable to prevent infection, and is widely known and is reported as occurring in infection caused by several viruses. This narrative review explores the ADE phenomenon, its occurrence in viral infections and evaluates its role in infection by SARS-CoV-2 virus, which causes coronavirus disease 2019 (COVID-19). As of yet, there is no clear evidence of ADE in SARS-CoV-2, though this area is still subject to further study.

摘要

抗体在免疫反应中起着至关重要的作用，既能抵御病原体，又能帮助产生强大的免疫记忆。抗体依赖的增强作用（ADE）发生在非中和抗体识别和结合病原体，但不能阻止感染时，这是广为人知的，并被报道发生在几种病毒引起的感染中。本综述探讨了 ADE 现象、其在病毒感染中的发生情况，并评估了其在导致 2019 年冠状病毒病（COVID-19）的 SARS-CoV-2 病毒感染中的作用。到目前为止，还没有 SARS-CoV-2 中存在 ADE 的明确证据，但这一领域仍在进一步研究中。