Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Autonomous University of Barcelona, 08035 Barcelona, Spain.
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spanish Institute of Health (ISCIII), 28029 Madrid, Spain.
Int J Mol Sci. 2022 Jun 2;23(11):6234. doi: 10.3390/ijms23116234.
The incidence and prevalence of diabetes are increasing worldwide, and cardiovascular disease (CVD) is the leading cause of death among subjects with type 2 diabetes (T2D). The assessment and stratification of cardiovascular risk in subjects with T2D is a challenge. Advanced glycation end products are heterogeneous molecules produced by non-enzymatic glycation of proteins, lipids, or nucleic acids. Accumulation of advanced glycation end products is increased in subjects with T2D and is considered to be one of the major pathogenic mechanism in developing complications in diabetes. Skin AGEs could be assessed by skin autofluorescence. This method has been validated and related to the presence of micro and macroangiopathy in individuals with type 2 diabetes. In this context, the aim of this review is to critically summarize current knowledge and scientific evidence on the relationship between skin AGEs and CVD in subjects with type 2 diabetes, with a brief reference to other diabetes-related complications.
糖尿病的发病率和患病率在全球范围内不断上升，心血管疾病（CVD）是 2 型糖尿病（T2D）患者死亡的主要原因。评估和分层 T2D 患者的心血管风险是一个挑战。晚期糖基化终产物是由蛋白质、脂质或核酸的非酶糖基化产生的异质分子。T2D 患者的晚期糖基化终产物积累增加，被认为是糖尿病并发症发展的主要致病机制之一。皮肤 AGEs 可以通过皮肤自发荧光来评估。这种方法已经得到验证，并与 2 型糖尿病个体的微血管和大血管病变的存在相关。在这种情况下，本综述的目的是批判性地总结目前关于 2 型糖尿病患者皮肤 AGEs 与 CVD 之间关系的知识和科学证据，并简要提及其他与糖尿病相关的并发症。
Zotero 插件