Faculty of Medicine, University of Medicine and Pharmacy "Gr. T. Popa", Iasi, Romania.
Int Urol Nephrol. 2012 Oct;44(5):1441-9. doi: 10.1007/s11255-011-0097-5. Epub 2011 Dec 10.
Advanced glycation end products (AGE), biomarkers of metabolic stress, are frequently encountered in chronic kidney disease (CKD) patients with cardiovascular disease. Our aim was to evaluate tissue accumulation of AGEs in CKD patients and possible correlations with traditional and non-traditional cardiovascular risk factors.
Skin AF was measured using AGE Reader in 310 patients: 157 haemodialysis patients (HD) (mean age 60 years, dialysis vintage 29 months, 19.1% diabetic), 102 peritoneal dialysis patients (PD) (mean age 56.3 years, dialysis vintage 16 months, 17.6% diabetic), 32 CKD patients (mean age 68 years, CKD duration 30 months, 34.4% diabetic) and 19 type 2 diabetic patients, without renal failure (mean age 59 years and median duration of diabetes 36 months).
HD patients have higher AGE levels compared to PD ones. Dialysis patients have the highest skin AF values compared to CKD patients (P < 0.05) and diabetic, without renal impairment, patients (P < 0.01). Skin AF levels in patients using ARBs and statins are comparable to those without treatment in dialysis group (HD + PD) but significantly different in PD sub-group and CKD patients. In dialysis patients, diabetes explains 17% of AGE values variance. In PD skin, AF correlates with CKD duration (P < 0.01) and dialysis vintage (P < 0.05). Skin AF values were significantly higher in anuric PD patients (P < 0.05). In our CKD group, we found no significant association with diabetes or GFR.
CKD patients have higher AGE values depending on duration (disease, RRT) and GFR (dialysis adequacy and RRF). Other important determinants were diabetes and age.
糖基化终产物（AGE）是代谢应激的生物标志物，在患有心血管疾病的慢性肾脏病（CKD）患者中经常出现。我们的目的是评估 CKD 患者体内 AGE 的积累情况，并研究其与传统和非传统心血管危险因素的可能相关性。
在 310 名患者中使用 AGE 阅读器测量皮肤 AGE 荧光（AF）：157 名血液透析患者（HD）（平均年龄 60 岁，透析龄 29 个月，19.1%为糖尿病患者），102 名腹膜透析患者（PD）（平均年龄 56.3 岁，透析龄 16 个月，17.6%为糖尿病患者），32 名 CKD 患者（平均年龄 68 岁，CKD 病程 30 个月，34.4%为糖尿病患者）和 19 名非肾衰竭的 2 型糖尿病患者（平均年龄 59 岁，糖尿病病程中位数为 36 个月）。
HD 患者的 AGE 水平高于 PD 患者。与 CKD 患者（P < 0.05）和无肾功能损害的糖尿病患者（P < 0.01）相比，透析患者的皮肤 AF 值最高。在使用 ARB 和他汀类药物的透析患者中，其皮肤 AF 值与未治疗的患者相当（HD + PD），但在 PD 亚组和 CKD 患者中则有显著差异。在透析患者中，糖尿病可解释 17%的 AGE 值变化。在 PD 皮肤中，AF 与 CKD 病程（P < 0.01）和透析龄（P < 0.05）相关。无尿 PD 患者的皮肤 AF 值明显更高（P < 0.05）。在我们的 CKD 组中，我们未发现糖尿病或肾小球滤过率（GFR）与 AGE 值之间有显著相关性。
CKD 患者的 AGE 值取决于病程（疾病、RRT）和 GFR（透析充分性和 RRF），此外，糖尿病和年龄也是重要的决定因素。
