Chen Jiahao, Dai Jingtao, Qian Junyu, Li Weirong, Li Ronghui, Pang Dong, Wan Guojiang, Li Ping, Xu Shulan
Department of Oral Implantology, Stomatological Hospital, Southern Medical University, Guangzhou 510280, China.
Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Materials (Basel). 2022 Jun 3;15(11):3991. doi: 10.3390/ma15113991.
High-purity magnesium (Mg) is a promising biodegradable metal for oral and maxillofacial implants. Appropriate surface roughness plays a critical role in the degradation behavior and the related cellular processes of biodegradable Mg-based metals. Nevertheless, the most optimized surface roughness has been questionable, especially for Mg-based oral and maxillofacial implants. Three representative scales of surface roughness were investigated in this study, including smooth (Sa < 0.5 µm), moderately rough (Sa between 1.0−2.0 µm), and rough (Sa > 2.0 µm). The results indicated that the degradation rate of the Mg specimen in the cell culture medium was significantly accelerated with increased surface roughness. Furthermore, an extract test revealed that Mg with different roughness did not induce an evident cytotoxic effect. Nonetheless, the smooth Mg surface had an adversely affected cell attachment. Therefore, the high-purity Mg with a moderately rough surface exhibited the most optimized balance between biodegradability and overall cytocompatibility.
高纯度镁（Mg）是一种用于口腔颌面植入物的很有前景的可生物降解金属。合适的表面粗糙度在可生物降解镁基金属的降解行为及相关细胞过程中起着关键作用。然而，最优化的表面粗糙度一直存在疑问，尤其是对于镁基口腔颌面植入物。本研究调查了三种具有代表性的表面粗糙度尺度，包括光滑（Sa < 0.5 µm）、中等粗糙（Sa在1.0 - 2.0 µm之间）和粗糙（Sa > 2.0 µm）。结果表明，随着表面粗糙度增加，镁试样在细胞培养基中的降解速率显著加快。此外，提取物试验表明，不同粗糙度的镁不会诱导明显的细胞毒性作用。尽管如此，光滑的镁表面对细胞附着有不利影响。因此，具有中等粗糙表面的高纯度镁在生物降解性和整体细胞相容性之间表现出最优化的平衡。
