Grillo Andrea, Barbato Vincenzo, Antonello Roberta Maria, Cola Marco Fabio, Parati Gianfranco, Salvi Paolo, Fabris Bruno, Bernardi Stella
Department of Medicine, Surgery and Health Sciences, University of Trieste, 34149 Trieste, Italy.
SC Medicina Clinica, ASUGI (Azienda Sanitaria Universitaria Giuliano Isontina), Cattinara Hospital, 34149 Trieste, Italy.
J Clin Med. 2022 Jun 1;11(11):3146. doi: 10.3390/jcm11113146.
Growing evidence shows that arterial stiffness measurement provides important prognostic information and improves clinical stratification of cardiovascular risk. Thyroid and parathyroid diseases are endocrine diseases with a relevant cardiovascular burden. The objective of this review was to consider the relationship between arterial stiffness and thyroid and parathyroid diseases in human clinical studies. We performed a systematic literature review of articles published in PubMed/MEDLINE from inception to December 2021, restricted to English languages and to human adults. We selected relevant articles about the relationship between arterial stiffness and thyroid and parathyroid diseases. For each selected article, data on arterial stiffness were extracted and factors that may have an impact on arterial stiffness were identified. We considered 24 papers concerning hypothyroidism, 9 hyperthyroidism and 16 primary hyperparathyroidism and hypoparathyroidism. Most studies evidenced an increase in arterial stiffness biomarkers in hypothyroidism, hyperthyroidism and primary hyperparathyroidism, even in subclinical and mild forms, although heterogeneity of measurement methods and of study designs prevented a definitive conclusion, suggesting that the assessment of arterial stiffness may be considered in the clinical evaluation of cardiovascular risk in these diseases.
越来越多的证据表明，动脉僵硬度测量可提供重要的预后信息，并改善心血管风险的临床分层。甲状腺和甲状旁腺疾病是具有相关心血管负担的内分泌疾病。本综述的目的是探讨人类临床研究中动脉僵硬度与甲状腺和甲状旁腺疾病之间的关系。我们对PubMed/MEDLINE自创建至2021年12月发表的文章进行了系统的文献综述，限于英文文献且研究对象为成年人群。我们筛选了有关动脉僵硬度与甲状腺和甲状旁腺疾病关系的相关文章。对于每篇选定的文章，提取了动脉僵硬度数据，并确定了可能影响动脉僵硬度的因素。我们纳入了24篇关于甲状腺功能减退、9篇关于甲状腺功能亢进以及16篇关于原发性甲状旁腺功能亢进和甲状旁腺功能减退的论文。大多数研究表明，在甲状腺功能减退、甲状腺功能亢进和原发性甲状旁腺功能亢进中，即使是亚临床和轻度形式，动脉僵硬度生物标志物也会升高，尽管测量方法和研究设计的异质性阻碍了得出明确结论，这表明在这些疾病的心血管风险临床评估中可考虑评估动脉僵硬度。
