孕早期脂联素水平降低与非裔美国女性早产高风险相关。
Decreased Adiponectin Levels in Early Pregnancy Are Associated with High Risk of Prematurity for African American Women.
作者信息
Lomakova Yelizavet D, Chen Xinhua, Stein T Peter, Steer Robert A
机构信息
Department of Obstetrics/Gynecology, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.
Department of Surgery, Rowan University School of Osteopathic Medicine, Stratford, NJ 08084, USA.
出版信息
J Clin Med. 2022 Jun 4;11(11):3213. doi: 10.3390/jcm11113213.
The relationship of low maternal serum adiponectin levels with preterm delivery among a multi-ethnic group has not been extensively investigated. We examined ethnic differences in cytokine/adipokine profiles and whether they contribute to several adverse pregnancy outcomes, particularly preterm delivery. Data and samples were from a large prospective observational cohort (n = 1776) of young, generally healthy pregnant women (African American 36.4%, Hispanic 48.0%, Caucasian 15.6%). Serum cytokine/adipokine concentrations were measured at entry (mean gestational age of 16.83 weeks) using the Liminex xMap Technology. Multivariable analyses were performed. A significant difference in adiponectin level was observed among ethnic groups. African Americans had a decreased adiponectin and increased resistin levels compared to Hispanics and Caucasians (p < 0.05 to p < 0.0001 for each). Decreased adiponectin (lowest quartile) was positively associated with preterm delivery independent of usual risk factors (adjusted odds ratio (AOR) 1.46, 95% confidence interval (CI) 1.05, 2.04 for all preterm and AOR 1.84, 95% CI 1.07, 3.17 for early preterm births). The results were unchanged when women with preeclampsia were excluded. Similar results were observed in African Americans. Decreased adiponectin levels were not related to preterm birth in either Hispanics or Caucasians. Lower adiponectin levels were also significantly associated with an increased risk of developing gestational diabetes (AOR 1.72, 95% CI 1.05, 2.84) and preeclampsia (AOR 1.45, 95% CI 1.00, 2.14) in the whole cohort and in Caucasians. We did not find any consistent relationships between the other markers with outcome variables. Dysregulation in maternal adiponectin at early gestation is associated with an increased risk of preterm delivery. An ethnic difference in adiponectin levels may contribute to a higher preterm delivery rate in African American women.
在一个多民族群体中，孕妇血清脂联素水平低与早产之间的关系尚未得到广泛研究。我们研究了细胞因子/脂肪因子谱的种族差异，以及它们是否会导致几种不良妊娠结局，尤其是早产。数据和样本来自一个大型前瞻性观察队列（n = 1776），该队列由年轻的、一般健康的孕妇组成（非裔美国人占36.4%，西班牙裔占48.0%，白种人占15.6%）。在入组时（平均孕周16.83周）使用Luminex xMap技术测量血清细胞因子/脂肪因子浓度。进行了多变量分析。观察到不同种族之间脂联素水平存在显著差异。与西班牙裔和白种人相比，非裔美国人的脂联素水平降低，抵抗素水平升高（每项p < 0.05至p < 0.0001）。脂联素降低（最低四分位数）与早产呈正相关，且独立于常见风险因素（所有早产的调整比值比（AOR）为1.46，95%置信区间（CI）为1.05, 2.04；早期早产的AOR为1.84，95%CI为1.07, 3.17）。排除子痫前期患者后结果不变。在非裔美国人中也观察到了类似结果。西班牙裔或白种人中脂联素水平降低与早产无关。在整个队列和白种人中，较低的脂联素水平也与发生妊娠期糖尿病（AOR 1.72，95%CI 1.05, 2.84）和子痫前期（AOR 1.45，95%CI 1.00, 2.14）的风险增加显著相关。我们未发现其他标志物与结局变量之间存在任何一致的关系。妊娠早期母体脂联素失调与早产风险增加有关。脂联素水平的种族差异可能导致非裔美国女性早产率较高。
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