Vicent Lourdes, Luna Raquel, Martínez-Sellés Manuel
Servicio de Cardiología, Hospital Universitario 12 de Octubre, and Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
Servicio de Cardiología, Hospital Universitario Gregorio Marañón, Calle Doctor Esquerdo, 46, 28007 Madrid, Spain.
J Clin Med. 2022 Jun 5;11(11):3217. doi: 10.3390/jcm11113217.
Infective endocarditis in children is a rare entity that poses multiple challenges. A history of congenital heart disease is the most common risk factor, although in recent years, other emerging predisposing conditions have gained relevance, such as central venous catheters carriers or children with chronic debilitating conditions; cases in previously healthy children with no medical history are also seen. Diagnosis is complex, although it has improved with the use of multimodal imaging techniques. Antibiotic treatment should be started early, according to causative microorganism and risk factors. Complications are frequent and continue to cause significant morbidity. Most studies have been conducted in adults and have been generalized to the pediatric population, with subsequent limitations. Our manuscript presents a comprehensive review of pediatric infective endocarditis, including recent advances in diagnosis and management.
儿童感染性心内膜炎是一种罕见疾病,带来诸多挑战。先天性心脏病病史是最常见的危险因素,不过近年来,其他新出现的易感因素也变得愈发重要,如中心静脉导管携带者或患有慢性衰弱性疾病的儿童;也可见于既往健康且无病史的儿童。诊断较为复杂,尽管多模态成像技术的应用使其有所改善。应根据致病微生物和危险因素尽早开始抗生素治疗。并发症很常见,持续导致显著的发病率。大多数研究是在成人中进行的,并推广至儿科人群,因而存在局限性。我们的论文对儿童感染性心内膜炎进行了全面综述,包括诊断和管理方面的最新进展。