Institute of Food Sciences and Technologies, Ajinomoto Co., Inc., Kawasaki 210-8681, Japan.
Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., Kawasaki 210-8681, Japan.
Nutrients. 2022 Jun 6;14(11):2357. doi: 10.3390/nu14112357.
The importance of maintaining good mental health with overall well-being has recently drawn attention from various spheres of academics and the working population. Amino acid intake has been reported to reduce depression symptoms and other mental health problems. However, the effectiveness of amino acid intake (i.e., single or combined) remains unknown. In this study, we assessed a combination of five amino acids (serine, alanine, glutamate, aspartate, and tyrosine; SAGAT) reported to regulate mental health.
A randomized, double-blind, placebo-controlled exploratory trial was conducted. Participants, aged between 20 and 65 years with fatigue sensation, were randomized to receive either SAGAT or the placebo and ingested them for four weeks. A transient mental work was loaded at day 0 and after four weeks of intervention. As the primary outcomes, the fatigue sensation was assessed. The mood status, cognitive function, work efficiency, and blood marker were also measured as secondary outcomes.
The number of participants analyzed for the efficacy evaluation were 20 in SAGAT and 22 in the placebo. There were no significant differences in the primary outcomes. However, as the secondary outcomes, the SAGAT group showed a significant improvement in motivation and cognitive function in the recovery period after mental work loaded in a four-week intervention compared to the placebo.
The current findings suggest that SAGAT contributes to maintaining proper motivation and cognitive function.
University Hospital Medical Information Network Clinical Trial Registry (ID: UMIN 000041221).
保持良好的心理健康和整体幸福感的重要性最近引起了学术界和工作人群的关注。据报道，摄入氨基酸可以减轻抑郁症状和其他心理健康问题。然而，氨基酸摄入（即单一或组合）的效果仍不清楚。在这项研究中，我们评估了一组五种氨基酸（丝氨酸、丙氨酸、谷氨酸、天冬氨酸和酪氨酸；SAGAT），据报道它们可以调节心理健康。
进行了一项随机、双盲、安慰剂对照的探索性试验。参与者年龄在 20 至 65 岁之间，有疲劳感，随机分为 SAGAT 组或安慰剂组，并服用四周。在第 0 天和干预四周后进行短暂的精神工作。疲劳感作为主要结果进行评估。情绪状态、认知功能、工作效率和血液标志物也作为次要结果进行测量。
对疗效评估进行分析的参与者人数为 SAGAT 组 20 人，安慰剂组 22 人。主要结果无显著差异。然而，作为次要结果，与安慰剂相比，SAGAT 组在为期四周的干预后进行精神工作的恢复期显示出动机和认知功能的显著改善。
目前的研究结果表明，SAGAT 有助于保持适当的动机和认知功能。
大学医院医学信息网络临床试验注册（注册号：UMIN 000041221）。
