Institute of Food Sciences and Technologies, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
Research Institute for Bioscience Products and Fine Chemicals, Ajinomoto Co., Inc, Kanagawa, 210-8681, Japan.
Eur J Nutr. 2024 Oct;63(7):2789-2799. doi: 10.1007/s00394-024-03464-1. Epub 2024 Jul 31.
The importance of maintaining good mental health with overall well-being has recently drawn attention from various fields. Functional peptides found from various protein sources reportedly reduce mental health problems. We found a new decapeptide (AJI-801) from whey proteins, which can possibly improve mood status and increase blood acetyl-L-carnitine (ALC) and fibroblast growth factor 21 (FGF21) levels. In this study, we assessed the effects of a single intake of whey protein hydrolysate containing a high amount of AJI-801 (WPH) on blood variables and mood status.
A randomized, double-blind, placebo-controlled cross-over trial of two doses of WPH (100 and 500 mg) was conducted. Participants, aged between 20 and 59 years with fatigue were allocated to two groups based on the WPH doses received, and set first test food in each study. The blood ALC and FGF21 levels at baseline and after 60, 120, and 180 min of test food intake were analyzed and the responses to the questionnaire items for mood status were obtained at baseline and after 60 and 180 min of test food intake.
There were no significant differences in the blood ALC and FGF21 levels between the two groups. As mood status, intake of 500-mg WPH (including 2.5-mg AJI-801) showed significant improvement in Depression/Dejection of the Profile of Mood States Questionnaire second edition and visual analog scale score for depression, as compared to the placebo.
Intake of AJI-801 500-mg WPH (including 2.5-mg AJI-801) contributes to the improvement of feeling down in healthy persons with fatigue.
University Hospital Medical Information Network Clinical Trial Registry (UMIN 000046829).
随着整体健康状况的提高，保持良好精神健康的重要性最近引起了各个领域的关注。据报道，从各种蛋白质来源中发现的功能性肽可以减少精神健康问题。我们从乳清蛋白中发现了一种新的十肽（AJI-801），它可能改善情绪状态，并增加血液乙酰左旋肉碱（ALC）和成纤维细胞生长因子 21（FGF21）水平。在这项研究中，我们评估了单次摄入含有大量 AJI-801 的乳清蛋白水解物（WPH）对血液变量和情绪状态的影响。
进行了一项随机、双盲、安慰剂对照的交叉试验，共纳入 2 个剂量的 WPH（100 和 500mg）。根据接受的 WPH 剂量，将年龄在 20 至 59 岁之间且有疲劳症状的参与者分为两组，并在每个研究中设定第一组测试食品。分析了基线和测试食品摄入后 60、120 和 180 分钟时的血液 ALC 和 FGF21 水平，并在基线和测试食品摄入后 60 和 180 分钟时获得了情绪状态问卷项目的反应。
两组间血液 ALC 和 FGF21 水平无显著差异。在情绪状态方面，与安慰剂相比，摄入 500mg WPH（含 2.5mg AJI-801）可显著改善第二代心境状态问卷的抑郁/沮丧和抑郁视觉模拟评分。
摄入含 2.5mg AJI-801 的 500mg WPH 有助于改善有疲劳感的健康人群的情绪低落。
大学医院医疗信息网临床试验注册（UMIN 000046829）。
