LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Molecules. 2022 May 29;27(11):3493. doi: 10.3390/molecules27113493.
Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the construction of more complex organic molecules. Concerning the reactivity of vinylpyrazoles, the topics surveyed herein include their use in cycloaddition reactions, free-radical polymerizations, halogenation and hydrohalogenation reactions, and more recently in transition-metal-catalyzed reactions, among other transformations. The current state of the art about vinylpyrazoles is presented with an eye to future developments regarding the chemistry of these interesting compounds. Styrylpyrazoles were not considered in this review, as they were the subject of a previous review article published in 2020.
乙烯基吡唑，也称为吡唑基烯烃，是有机化学中有趣的结构单元，但一直被忽视。本文综述了乙烯基吡唑的性质和合成途径，并强调了它们作为构建更复杂有机分子的砌块的多功能性。关于乙烯基吡唑的反应性，本文综述的主题包括它们在环加成反应、自由基聚合、卤化和卤氢反应中的应用，以及最近在过渡金属催化反应中的应用等转化。本文介绍了乙烯基吡唑的最新研究进展，以期为这些有趣化合物的化学研究提供参考。苯乙烯基吡唑不在本文综述范围内，因为它们是 2020 年发表的一篇综述文章的主题。
