Faria Jéssica Venância, Vegi Percilene Fazolin, Miguita Ana Gabriella Carvalho, Dos Santos Maurício Silva, Boechat Nubia, Bernardino Alice Maria Rolim
Programa de Pós-Graduação em Química,Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil; Fundação Oswaldo Cruz - Fiocruz, Instituto de Tecnologia em Fármacos - Farmanguinhos, Manguinhos, RJ, Brazil.
Programa de Pós-Graduação em Química,Instituto de Química, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Bioorg Med Chem. 2017 Nov 1;25(21):5891-5903. doi: 10.1016/j.bmc.2017.09.035. Epub 2017 Sep 23.
The pyrazole nucleus is an aromatic azole heterocycle with two adjacent nitrogen atoms. Pyrazole derivatives have exhibited a broad spectrum of biological activities, and approved pyrazole-containing drugs include celecoxib, antipyrine, phenylbutazone, rimonabant, and dipyrone. Many research groups have synthesized and evaluated pyrazoles against several biological agents. This review examines recent publications relating the structures of pyrazoles with their corresponding biological activities.
吡唑核是一种具有两个相邻氮原子的芳香唑杂环。吡唑衍生物已展现出广泛的生物活性，已获批准的含吡唑药物包括塞来昔布、安替匹林、保泰松、利莫那班和安乃近。许多研究小组已合成并评估了针对多种生物制剂的吡唑。本综述考察了近期将吡唑结构与其相应生物活性相关联的出版物。
