School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.
Shaanxi Xi'an Lantian County Food and Drug Inspection Testing Center, Xi'an 710500, China.
Molecules. 2022 May 30;27(11):3495. doi: 10.3390/molecules27113495.
Bacterial cellulose (BC) is well known as a high-performance dietary fiber. This study investigates the adsorption capacity of BC for cholesterol, sodium cholate, unsaturated oil, and heavy metal ions in vitro. Further, a hyperlipidemia mouse model was constructed to investigate the effects of BC on lipid metabolism, antioxidant levels, and intestinal microflora. The results showed that the maximum adsorption capacities of BC for cholesterol, sodium cholate, Pb and Cr were 11.910, 16.149, 238.337, 1.525 and 1.809 mg/g, respectively. Additionally, BC reduced the blood lipid levels, regulated the peroxide levels, and ameliorated the liver injury in hyperlipidemia mice. Analysis of the intestinal flora revealed that BC improved the bacterial community of intestinal microflora in hyperlipidemia mice. It was found that the abundance of was increased, while the abundance of and was decreased at the phylum level. In addition, increased abundance of and decreased abundance of and were obtained at the genus level. These changes were supposed to be beneficial to the activities of intestinal microflora. To conclude, the findings prove the role of BC in improving lipid metabolism in hyperlipidemia mice and provide a theoretical basis for the utilization of BC in functional food.
细菌纤维素（BC）作为一种高性能膳食纤维而广为人知。本研究考察了 BC 对胆固醇、胆酸钠、不饱和油和重金属离子的体外吸附能力。此外，构建了高脂血症小鼠模型，以研究 BC 对脂代谢、抗氧化水平和肠道微生物群的影响。结果表明，BC 对胆固醇、胆酸钠、Pb 和 Cr 的最大吸附容量分别为 11.910、16.149、238.337、1.525 和 1.809mg/g。此外，BC 降低了高血脂小鼠的血脂水平，调节了过氧化物水平，改善了肝损伤。肠道菌群分析表明，BC 改善了高血脂小鼠肠道微生物菌群的细菌群落。发现在门水平， 的丰度增加，而 和 的丰度降低。此外，在属水平上， 的丰度增加， 和 的丰度减少。这些变化可能有利于肠道微生物群的活性。总之，这些发现证明了 BC 在改善高血脂小鼠脂代谢中的作用，并为 BC 在功能性食品中的利用提供了理论依据。
