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菲衍生物对 A549 肺癌细胞的抗增殖和促凋亡作用。

Antiproliferative and Proapoptotic Effects of Phenanthrene Derivatives Isolated from on A549 Lung Cancer Cells.

机构信息

State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

出版信息

Molecules. 2022 May 30;27(11):3519. doi: 10.3390/molecules27113519.

DOI:10.3390/molecules27113519
PMID:35684456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9181924/
Abstract

Lung cancer continues to be the world's leading cause of cancer death and the treatment of non-small cell lung cancer (NSCLC) has attracted much attention. The tubers of are regarded as "an excellent medicine for lung diseases" and as the first choice to treat several lung diseases. In this study, seventeen phenanthrene derivatives, including two new compounds ( and ), were isolated from the tubers of . Most compounds showed cytotoxicity against A549 cells. An EdU proliferation assay, a cell cycle assay, a wound healing assay, a transwell migration assay, a flow cytometry assay, and a western blot assay were performed to further investigate the effect of compound on A549 cells. The results showed that compound inhibited cell proliferation and migration and promoted cell apoptosis in A549 cells. The mechanisms might correlate with the regulation of the Akt, MEK/ERK, and Bcl-2/Bax signaling pathways. These results suggested that the phenanthrenes of might be important and effective substances in the treatment of NSCLC.

摘要

肺癌仍然是全球癌症死亡的主要原因，非小细胞肺癌（NSCLC）的治疗引起了广泛关注。 被视为“肺病的良药”，是治疗多种肺病的首选药物。在这项研究中，从 块茎中分离出十七种菲衍生物，包括两种新化合物（ 和 ）。大多数化合物对 A549 细胞表现出细胞毒性。进行了 EdU 增殖测定、细胞周期测定、划痕愈合测定、Transwell 迁移测定、流式细胞术测定和 Western blot 测定，以进一步研究化合物 对 A549 细胞的作用。结果表明，化合物 抑制 A549 细胞的增殖和迁移，并促进细胞凋亡。其机制可能与调节 Akt、MEK/ERK 和 Bcl-2/Bax 信号通路有关。这些结果表明， 中的菲类化合物可能是治疗 NSCLC 的重要有效物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/7ce47ba617c8/molecules-27-03519-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/0426a0c9e297/molecules-27-03519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/c94a5256522e/molecules-27-03519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/bc9cc4061a01/molecules-27-03519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/e77349babec2/molecules-27-03519-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/0d54b40655fc/molecules-27-03519-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/da13ad950e1f/molecules-27-03519-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/7ce47ba617c8/molecules-27-03519-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/0426a0c9e297/molecules-27-03519-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/c94a5256522e/molecules-27-03519-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/bc9cc4061a01/molecules-27-03519-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/e77349babec2/molecules-27-03519-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/0d54b40655fc/molecules-27-03519-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/da13ad950e1f/molecules-27-03519-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27c/9181924/7ce47ba617c8/molecules-27-03519-g007.jpg

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