Ariafar Ali, Zeighami Shahryar, Salehipour Mehdi, Ahmed Faisal, Saeedi Sara, Nikbakht Hossein-Ali
Department of Urology, School of Medicine, Shiraz University of Medical Since, Shiraz, Iran.
Urology Oncology Research Center, Shiraz University of Medical Since, Shiraz, Iran.
Med J Islam Repub Iran. 2021 Dec 27;35. doi: 10.47176/mjiri.35.176. eCollection 2021.
The oncological outcomes of bladder cancer are directly associated with disease pathology and surgical technique. Therefore, we investigated the pathologic factors of radical cystectomy (RC) specimens. In this retrospective study, 365 patients who underwent RC between March 2013 to March 2018 in hospitals affiliated to Shiraz University were enrolled. The patients' clinicopathological parameters, such as tumor type, tumor grade, carcinoma in situ, lymph node (LN) involvement, lymphovascular invasion (LVI), perineural invasion (PNI), and age, were recorded from their pathology reports. For comparison of variables, an independent t test was used. P < 0.05 was regarded as significant. The statistical software SPSS version 22 was used to examine the data. The participants' mean age was 64.52 ± 11.54 years, and 320 (87.7%) patients were men and 45 (12.3%) were women. The mean dissected LN was 9.69 ± 8.70 nodes and 1.06 ±3.49 of the dissected LNs were involved by tumor. PNI and perivesical invasion were presented in 148 (40.5%) and 96 (26.3%) patients, respectively. Ureteral, urethral, and prostate involvements were seen in 23 (6.3%), 50 (13.7%), and 66 (18.1%) patients. Most patients had pathologic tumor stage 2 (36.4%). Factors such as LVI, PNI, perivesical invasion, and prostate involvement, were strongly correlated with positive LN (P ≤ 0.05). The examination of the RC specimen is critical for patient care, outcome, and justification of adjuvant therapy. Factors such as LVI, perineural invasion, perivesical invasion, and prostate involvement were strongly correlated with positive LN.
膀胱癌的肿瘤学结局与疾病病理和手术技术直接相关。因此，我们研究了根治性膀胱切除术（RC）标本的病理因素。在这项回顾性研究中，纳入了2013年3月至2018年3月在设拉子大学附属医院接受RC手术的365例患者。从他们的病理报告中记录患者的临床病理参数，如肿瘤类型、肿瘤分级、原位癌、淋巴结（LN）受累情况、淋巴管浸润（LVI）、神经周围浸润（PNI）和年龄。为比较变量，采用独立t检验。P<0.05被视为具有统计学意义。使用统计软件SPSS 22版对数据进行分析。参与者的平均年龄为64.52±11.54岁，320例（87.7%）患者为男性，45例（12.3%）为女性。平均切除的淋巴结为9.69±8.70个，其中1.06±3.49个被肿瘤累及。分别有148例（40.5%）和96例（26.3%）患者存在PNI和膀胱周围浸润。输尿管、尿道和前列腺受累分别见于23例（6.3%）、50例（13.7%）和66例（18.1%）患者。大多数患者的病理肿瘤分期为2期（36.4%）。LVI、PNI、膀胱周围浸润和前列腺受累等因素与阳性LN密切相关（P≤0.05）。对RC标本的检查对于患者护理、预后以及辅助治疗的合理性至关重要。LVI、神经周围浸润、膀胱周围浸润和前列腺受累等因素与阳性LN密切相关。
