Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.
Department of Urology, Medical University of Vienna, Vienna, Austria.
World J Urol. 2018 Feb;36(2):157-170. doi: 10.1007/s00345-017-2115-4. Epub 2017 Nov 16.
To review the currently available literature reporting the patterns of recurrence and their predictive factors after open radical cystectomy (RC) for bladder cancer.
A review of the literature was performed using the MEDLINE, Scopus and Web of Sciences databases from January 1997 to May 2017. The PRISMA guidelines were followed for the conduct of the study.
Local recurrence rate ranges between 30 and 54%. Distant recurrence is not often standardized and is reported in up to 50% of cases. The overall 5-year recurrence-free survival rates from 58 to 81%. The mean follow-up of studies included in the analysis ranged from 18 to 350 months. Details on the most important demographic and epidemiological, clinical, histologic and pathologic predictors of recurrence after radical cystectomy are provided through an evidence-based approach. The impact of the extension of lymph node dissection on recurrence after RC is investigated.
A correct prognostic assessment is essential for patients undergoing radical cystectomy for bladder cancer, thereby potentially improving their oncologic outcomes.
回顾目前有关膀胱癌根治性膀胱切除术（RC）后复发模式及其预测因素的文献。
检索 1997 年 1 月至 2017 年 5 月期间 MEDLINE、Scopus 和 Web of Sciences 数据库，采用 PRISMA 指南进行研究。
局部复发率为 30%至 54%之间。远处复发并不常见，多达 50%的病例报告有远处复发。5 年无复发生存率为 58%至 81%。分析中纳入的研究的平均随访时间为 18 至 350 个月。通过循证方法提供了有关根治性膀胱切除术后复发最重要的人口统计学和流行病学、临床、组织学和病理学预测因素的详细信息。还探讨了淋巴结清扫术范围对 RC 后复发的影响。
对膀胱癌行根治性膀胱切除术的患者进行正确的预后评估至关重要，从而可能改善其肿瘤学结局。
