Hagerman R J, Falkenstein A R
Clin Pediatr (Phila). 1987 May;26(5):253-7. doi: 10.1177/000992288702600508.
An association between the frequency of otitis media in early childhood and later hyperactivity is reported in this study. The subjects were 67 children referred to a child development clinic for evaluation of school failure. Ranging from 6 to 13 years old, all the children demonstrated specific school learning problems, and 27 were also considered hyperactive by two or more raters. Sixteen of the hyperactive children were treated with central nervous system stimulant medication. In retrospect, there was positive correlation between an increasing number of otitis media infections in early childhood and the presence and severity of hyperactive behavior. Ninety-four percent of children medicated for hyperactivity had three or more otitis infections, and 69 percent had greater than 10 infections. In comparison, 50 percent of non-hyperactive school-failure patients had three or more infections and 20 percent had greater than 10 infections. Twenty-two of 28 children (79%) known to have more than 10 infections experienced recurrent otitis before 1 year of age.
本研究报告了幼儿期中耳炎发病频率与后期多动之间的关联。研究对象为67名因学业失败前来儿童发育诊所评估的儿童。所有儿童年龄在6至13岁之间，均表现出特定的学校学习问题，其中27名儿童被两名或更多评估者认定为多动。16名多动儿童接受了中枢神经系统兴奋剂药物治疗。回顾发现，幼儿期中耳炎感染次数增加与多动行为的存在及严重程度呈正相关。接受多动治疗的儿童中，94%有三次或更多次耳部感染，69%有超过10次感染。相比之下，学业失败的非多动患儿中，50%有三次或更多次感染，20%有超过10次感染。已知有超过10次感染的28名儿童中，22名（79%）在1岁前曾反复患中耳炎。
