Kilgour R D, Riggs C E
Diabetes Res. 1987 Jan;4(1):27-9.
The effect of 30 min of myocardial ischemia on cardiac glycogenolysis and lactate accumulation was investigated in streptozotocin (STZ) diabetic and normal rats. In normal rats, ischemia caused a significant reduction in cardiac glycogen and a significant increase in cardiac lactate. STZ rats experienced a similar, but larger, reduction in cardiac glycogen with ischemia but did not accumulate significant quantities of lactic acid suggesting that diabetic rats have a reduced capacity for non-oxidative carbohydrate metabolism in myocardial ischemia.
研究了链脲佐菌素（STZ）诱导的糖尿病大鼠和正常大鼠心肌缺血30分钟对心脏糖原分解和乳酸积累的影响。在正常大鼠中，缺血导致心脏糖原显著减少，心脏乳酸显著增加。STZ大鼠在缺血时心脏糖原也有类似但更大程度的减少，但未积累大量乳酸，这表明糖尿病大鼠在心肌缺血时非氧化碳水化合物代谢能力降低。
