The First Affiliated Hospital of Soochow University Department of Anesthesiology, Suzhou 215006, Jiangsu, China.
The Affiliated Hospital of Xuzhou Medical University Department of Pain, Xuzhou 221000, Jiangsu, China.
Contrast Media Mol Imaging. 2022 May 30;2022:1579937. doi: 10.1155/2022/1579937. eCollection 2022.
This study evaluated the effectiveness and safety of botulinum toxin type A (BoNT-A) and pulsed radiofrequency (RF) in the clinical treatment of postherpetic neuralgia (PHN). A total of 100 patients with PHN were randomly divided into two groups ( = 50 per group): RF group and BoNT-A group. Based on conventional drug treatment, patients were treated with either a single nerve root pulsed radiofrequency therapy or a single local subcutaneous injection of BoNT-A in the lesion area. All the patients were followed up for 24 weeks on pain scores, sleep quality, anxiety, and depression scores, etc. In the last follow-up at the end of 24 weeks postoperation, the pain scores of patients in both groups were significantly lower than those before the operation ( < 0.05), indicating that both treatments were effective against PHN; however, there was no significant difference between these two groups ( > 0.05). It is noteworthy that the subcutaneous injection of BoNT-A is relatively easy to administer and less expensive compared to RF. Therefore, we believe that the subcutaneous injection of BoNT-A is an effective and safe method for the treatment of PHN.
本研究评估了肉毒毒素 A 型（BoNT-A）和脉冲射频（RF）在治疗带状疱疹后神经痛（PHN）中的有效性和安全性。共 100 例 PHN 患者随机分为两组（每组 n=50）：RF 组和 BoNT-A 组。在常规药物治疗的基础上，RF 组患者接受单根神经根脉冲射频治疗，BoNT-A 组患者在皮损区域接受单次局部皮下注射 BoNT-A。所有患者均随访 24 周，记录疼痛评分、睡眠质量、焦虑和抑郁评分等。在术后 24 周的最后一次随访中，两组患者的疼痛评分均明显低于术前（<0.05），表明两种治疗方法均对 PHN 有效；但两组之间无显著差异（>0.05）。值得注意的是，与 RF 相比，BoNT-A 皮下注射相对容易操作且费用较低。因此，我们认为 BoNT-A 皮下注射是治疗 PHN 的一种有效且安全的方法。
