The Department of Cardiology, Fourth Hospital of Hebei Medical University, Shijiangzhuang, Hebei 050011, China.
The Department of Haematology, Fourth Hospital of Hebei Medical University, Shijiangzhuang, Hebei 050011, China.
Scanning. 2022 May 28;2022:4728921. doi: 10.1155/2022/4728921. eCollection 2022.
Detection of arterial stiffness is an important method to predict the occurrence of hypertension complications and to screen patients with high cardiovascular risk. In order to predict the damage of AASI to the renal function of patients with essential hypertension, the prediction of AASI based on stepwise Regression equation scanning for renal function damage in patients with essential hypertension is proposed. Measure the 24 h ambulatory blood pressure of the selected subjects, establish a linear Regression equation scanning, and calculate the slope of the straight line, and finally, the slope is AASI. According to the quartiles, AASI is divided into four parts: group I < 0.53 ( = 49); 0.53 ≤ group II < 0.60 ( = 51); 0.60 ≤ group III < 0.69 ( = 48); group IV ≥ 0.69 ( = 44). Experiment result shows the following: with the increase of AASI, cystatin (CysC) also increased significantly, while CysC-eGFR decreased significantly ( < 0.05). Compared with groups I, II, and III, Scr and CysC in group IV increased ( < 0.05), and Ccr, CysC-eGFR, and (CKD-EPI)-eGFR all decreased ( < 0.05). AASI is positively correlated with CysC performance, and the correlation coefficient is 0.637. It is negatively correlated with Ccr performance, and is -0.361. It is negatively correlated with CysC-eGFR, and is -0.698. And it is negatively correlated with (CKD-EPI)-eGFR, and is -0.331. Age and 24 h PP also showed an increasing trend with the increase of AASI, and it suggests that age may be an influencing factor that promotes kidney damage caused by hypertension; it also suggests that AASI can be used as a new indicator of arterial compliance; AASI is linearly related to various indicators of renal damage and can be used as a predictive indicator of renal damage caused by essential hypertension; cystatin C and the estimated glomerular filtration rate CysC-eGFR based on cystatin C are better than other indicators reflecting glomerular filtration rate, more sensitively assess the degree of early renal damage. Obesity may also be a factor that promotes kidney damage caused by hypertension.
动脉僵硬度的检测是预测高血压并发症发生和筛查心血管高危患者的重要方法。为了预测 AASI 对原发性高血压患者肾功能的损害，提出了基于逐步回归方程扫描预测原发性高血压患者肾功能损害的 AASI。测量所选受试者的 24 小时动态血压，建立线性回归方程扫描，计算直线斜率，最后斜率即为 AASI。根据四分位数，AASI 分为四部分：I 组<0.53(=49)；0.53≤II 组<0.60(=51)；0.60≤III 组<0.69(=48)；IV 组≥0.69(=44)。实验结果表明：随着 AASI 的增加，胱抑素 C(CysC)也明显升高，而 CysC-eGFR 明显降低(<0.05)。与 I、II、III 组相比，IV 组 Scr 和 CysC 升高(<0.05)，Ccr、CysC-eGFR 和(CKD-EPI)-eGFR 降低(<0.05)。AASI 与 CysC 呈正相关，相关系数为 0.637。与 Ccr 呈负相关，相关系数为-0.361。与 CysC-eGFR 呈负相关，相关系数为-0.698。与(CKD-EPI)-eGFR 呈负相关，相关系数为-0.331。年龄和 24 h PP 也随着 AASI 的增加呈上升趋势，这表明年龄可能是促进高血压引起的肾脏损害的一个影响因素；这也表明 AASI 可以作为动脉顺应性的新指标；AASI 与肾脏损害的各种指标呈线性相关，可作为原发性高血压引起的肾脏损害的预测指标；基于胱抑素 C 的肾小球滤过率估计值 CysC-eGFR 比其他反映肾小球滤过率的指标更好，更能敏感地评估早期肾脏损害的程度。肥胖也可能是促进高血压引起的肾脏损害的一个因素。
