Department of Chemistry, University of Delhi, New Delhi, India.
Tuberculosis Research Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India.
J Biochem Mol Toxicol. 2022 Sep;36(9):e23123. doi: 10.1002/jbt.23123. Epub 2022 Jun 10.
A series of 2,5-disubstituted benzimidazole derivatives was synthesized with the aim to identify compounds with potent anti-TB activity. All the compounds were screened in vitro against cultured Mycobacterium tuberculosis H Rv strain and found to be exhibiting MIC values in the range of 0.195-100 µM. Out of 43 synthesized compounds, two compounds 11h and 13e showed better anti-TB activity than the reference drug isoniazid.
我们合成了一系列 2,5-二取代苯并咪唑衍生物，旨在寻找具有高效抗结核活性的化合物。所有化合物均在体外对培养的结核分枝杆菌 H37Rv 株进行了筛选，结果显示其 MIC 值在 0.195-100 μM 范围内。在所合成的 43 种化合物中，化合物 11h 和 13e 的抗结核活性优于对照药物异烟肼。
